View source for ASLO

'''ASLO (antistreptolysin titer)''', is the titre of antibodies against [https://en.wikipedia.org/wiki/Streptolysin streptolysin O], increases in 3-6 weeks after [[Streptococcus|streptococcal]] infection and decreases in 6-12 months. For this reason, its use in the diagnosis of acute infection is completely irrelevant. There is '''only one indication''' for its determination, namely the suspicion of '''[https://en.wikipedia.org/wiki/Rheumatic_fever acute rheumatic fever]''' or '''[https://en.wikipedia.org/wiki/Acute_proliferative_glomerulonephritis post-streptococcal glomerulonephritis]'''. Following skin infections, the antibody titer increases slightly because streptolysin O is already inhibited in the skin. 
 Streptolysin O (SLO) is a substance produced by almost all strains of pyogenic streptococcus (as well as group C and G strains). Unlike streptolysin S, it is reversibly inhibited by oxygen - hence the designation O.

== Links ==
=== Literature ===

* PAVELKA, Jan, Pavel HORNÍK a Peter MIKOLÁŠEK, et al. Běžné streptokokové infekce – mýty a omyly. ''Pediatrie pro praxi'' [online]''. ''2011, roč. 12, vol. 6, s. 414-415

[[Category:Immunology]]