View source for Regulation of ketogenesis


Regulation of [[Formation of ketone bodies|ketogenesis]] takes place at '''four levels''':

# '''Hormone-sensitive lipase''' – lipolysis in [[adipose tissue]].
# '''Carnitine acyltransferase I''' – entry of  [[fatty acids]] into [[Mitochondria and their structure|mitochondria]], where their [[Beta-oxidation|β-oxidation]] takes place.
# '''Routing of acetyl-CoA from β-oxidation to ketogenesis and not to the [[Citric acid cycle (FBLT)|Krebs cycle]]''' .
# '''Mitochondrial HMG-CoA synthase'''.

A high level of ketone bodies in the blood signals the presence of a large amount of acetyl-CoA. Its consequence is the inhibition of [[Lipids as an energy source|lipolysis]].

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[[Category:Biochemistry]]
[[Category:FBLT]]