View source for Serotonin syndrome

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[[File:Serotonin.png|thumb|Serotonin]]
'''Serotonin syndrome''' is a life-threatening condition that is caused by elevated levels of serotonin . It most often occurs after the use of [[SSRIs]] in combination with [[monoamine oxidase inhibitors]] , the use of light opioids such as ''tramadol'' , or during treatment with [[Lithium (pharmacology)|lithium]]. 

=== Division ===
We can divide this condition according to the area of the nervous system that is affected
* '''central''' – includes conditions such as confusion, dysarthria , tremor , agitation, mania;<ref>
{{Cite
| type = book
| isbn = 80-7262-168-8
| surname1 = Lincová
| name1 = Dagmar
| others = yes
| title = Základní a aplikovaná farmakologie
| edition = 1
| publisher = GALÉN
| year = 2002
| pages = 601
}}
</ref>
* '''periferal''' – where we can observe convulsions, flatulence , hypertension and tachycardia.

According to the functions that are affected, it can be divided into:
* cognitive – cefalea , agitation, hallucinations;
* autonomic – hypertermia, [[vasoconstriction]], [[nausea]], [[diarrhea]];
* somatic – myoclonus , hyperreflexia, tremor;

Devision to '''central''' a '''periferal''' is used more.

=== Cause ===
Serotonin syndrome is not an adverse effect in the idiopathic sense, but is an expected condition of elevated serotonin levels. This effect is due to interactions at the '''[[Cytochrom P450|cytochromu P450]] level'''. Interactions can occur, for example, with propranolol , theophylline , benzodiazepines and many other drugs. 
A genetic polymorphism in cytochrome P450 enzymes, which occurs in 10 to 20% of the population, also contributes to serotonin syndrome.
=== Treatment ===
Serotonin syndrome can be prevented by administering cyproheptadine, which is a 1st generation [[Antihistamines|antihistamine]] and also has antiserotonin effects

== Links ==
=== Related articles ===
* [[SSRI]]
* [[Serotonin]]
* [[Antidepresiva]]

=== Used literature ===
* {{Cite
| type = book
| isbn = 80-7262-168-8
| surname1 = Lincová
| name1 = Dagmar
| others = yes
| title = Základní a aplikovaná farmakologie
| edition = 1
| publisher = GALÉN
| year = 2002
| pages = 601
}}
* {{Cite
| type = book
| isbn = 80-7254-181-1
| surname1 = Hynie
| name1 = Sixtus
| title = Farmakologie v kostce
| edition = 2
| location = Praha
| publisher = Triton
| year = 2001
| pages = 520
}}
=== Refereces ===
<references />