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'''Syphilis''' ('''acute, lues''' or '''lues venerea''') is a worldwide infectious chronic systemic disease with a characteristic course of alternating symptomatic and asymptomatic periods. It is transmitted mainly through sexual intercourse. 

== Treponema pallidum ==
The causative agent of syphilis is an anaerobic spiral fibrous bacteria belonging to spirochetes. It is primarily pathogenic to humans, who are its only host in nature. 

=== Pathogenicity ===
Treponema pallidum is naturally pathogenic to humans only. There are three possible transmission paths:
# sexual intercourse;
# transmission by contaminated objects;
# penetration through the placenta and infection of the fetus ([[Vrozená syfilis|adrenal syphilis]] develops).

By far the most common transmission is sexual intercourse, because the resistance of T. pallidum is very low and it dies quickly when away from the body. It is destroyed by oxygen, temperatures above 39 ° C, diluted solutions of common disinfectants and dies in blood cans within 4 hours. Transmission by contaminated objects is extremely rare. 

=== Pathogeneses ===
Treponema pallidum penetrates the body through the mucous membranes or skin. It multiplies  '''extracellularly''' and does not have a chemotactic effect on polymorphonuclear leukocytes. Virulent strains are coated with a mucous layer that prevents treponem from killing in phagocytes and from attaching complement or antibodies to its surface. Morphological changes (characteristic of all stages) are caused by '''capillary endothelial damage''' and dysfunction. It is not the bacteria themselves but the '''immunopathological processes''' that arise in response to the presence of Treponem in the body and which lead to extensive destruction at a time when Treponemas are almost eliminated from the body.
;Causes of syphilis symptoms:
# capillary endothelial damage;
# immunopathological changes:
#* immunocomplexes of antigens and antibodies (antigens are largely released during the breakdown of bacteria);
#* cell hypersensitivity.

=== Imunita ===
Specific immunity (both antibody and cellular) against treponemas develops during the course of the disease. Cell hypersensitivity is due to activation of macrophages. Immune reactions can lead to complete recovery in the untreated. Protection against a new infection is only in the early stages, reinfection is possible. 

* It can affect virtually any tissue or organ, and untreated disease can cause death or disability. The infection can be transmitted to the [[Plod|fetus]]<nowiki/>during pregnancy (early and late [[Vrozená syfilis|congenital syphilis]]).<ref name="Dostál">{{Cite|type = book|surname1 = DOSTÁL|name1 = Václav|others = yes|title = Infektologie|edition = 1|location = Praha|publisher = Karolinum|year = 2005|isbn = 80-246-0749-2}}</ref>
<gallery>
Image:TreponemaPallidum.jpg|''T. pallidum'' v elektronovém mikroskopu.
Image:Treponema pallidum.jpg|''Treponema pallidum''.
</gallery>

== Characteristics ==
[[Image:Syphilis.webm|thumb| Syphilis (video).]]
* Incidence in the Czech Republic in 2009: 997 cases (ie 10 per 100 thousand inhabitants, of which 22% of foreigners), in 2006: 502 cases (5 per 100 thousand inhabitants).<ref>
{{Cite
| type = web
| surname1 = Ústav zdravotnických informací a statistiky ČR
| others = yes
| url = http://www.uzis.cz/category/klicova-slova/zdravotni-stav/pohlavni-nemoci
| source_name = Pohlavní nemoci 2009
| cited = 2011-07-17
}}
</ref>

* Originator: spirocheta Treponema pallidum.
* Transmission: sexual intercourse, transplacental, blood transfusion.
* Place of entry: any area of skin and mucous membranes, most often the genital, rectal and oral mucosa.
* Incubation period: 21 days (9-90 days).<ref>{{Cite| type = article| surname1 = Poláčková| name1 = Z| article = Pohlavní choroby I. díl| journal = Dermatologie pro praxi| url = http://www.solen.cz/pdfs/der/2008/02/06.pdf| year = 2008| volume = 2| pages = 74-76| issn = -}}</ref>
* Risk groups: drug [[Drogy|addicts]], patients with [[AIDS]].
* It is infectious from primary infection until the end of the 2nd year of the disease (ie stage 1 and 2).<ref name="Seidel">{{Cite|type = book|surname1 = SEIDL|name1 = Zdeněk|surname2 = OBENBERGER|name2 = Jiří|others = no|title = Neurologie pro studium i praxi|edition = 2|location = Praha|publisher = Grada Publishing|year = 2004|isbn = 80-247-0623-7}}</ref> Isolation in the venereology department is therefore mandatory in patients with stage 1 and 2 syphilis.<ref>{{Cite| type = legislative_publication| country = Česká republika| document = Sbírka zákonů č. 275 / 2010| year = 2010| url = http://www.szu.cz/uploads/sb103_10_1_novela.pdf}}</ref>
* Subject to reporting.
* There is no vaccination.

== Clinical picture ==
{{Edit article|Syphilis (clinical picture)}}{{:Syphilis (clinical picture)}}

== Diagnostics ==
* clinical picture, anamnesis
* indirect diagnostics - serological examination of antibodies:
** non-treponemal tests (VDRL, RRR) - show non-specific anticardiolipin antibodies ("reagins")
** treponema tests (TPHA, FTA, ELISA, ...) - show specific antibodies against Treponema pallidum antigens
** Non-specific antibodies disappear within weeks to months after effective treatment, but specific IgG remains detectable over a long period of time.<ref>http://www.medmicro.info/portal/syfilis/lvl3/ch09.html</ref>
* direct diagnostics:
** examination under a shadow microscope
*** basic, standard examination in case of suspicion of a specific lesion on the skin or mucosa
*** allows to examine serous exudate from lesions, cerebrospinal fluid, amniotic fluid, etc.
** PCR (polymerase chain reaction)
** direct immunofluorescence antigen detection (DFA-TP) - expensive, not available in our country
** histopathological examination (silver impregnation) - lengthy and burdened with a number of artifacts<ref name="szu">http://www.szu.cz/tema/prevence/syfilis-tradicni-choroba-soucasny-problem-ii</ref>

=== Serological examinations ===
* '''RRR''' (Rapid Reaction Reaction) or RPR (Rapid Plasma Reagin) - a cheap '''''screening test'''''
** microflocculation reactions where the antigen is cardiolipin mixed with cholesterol and lecithin
** Cardiolipin is a phospholipid (hapten) contained in the membrane of Treponema pallidum, but also in other bacteria and also in mitochondria
** anti-cardiolipin antibodies produced in syphilis are called "reagents"
** clusters form when the antigen meets the antibodies
** may be false positive (for tumors, pregnancy, malaria), therefore positivity needs to be confirmed eg by TPHA test<ref name="mikroLF3">http://mikrobiologie.lf3.cuni.cz/mikrobiologie/bak/uceb/obsah/lues/lues.htm</ref>
* '''VDRL''' (Venereal disease research laboratory) microscopic test
** can be used to test serum and cerebrospinal fluid<ref name="szu"/>
* '''TPHA''' (Treponema pallidum hemagglutination) or MHA-TP (micro hemagglutination of T. pallidum) - cheap '''screening test'''
** antigen, T. pallidum ssp. pallidum Nichols (so-called Nichols strain) is bound to chicken erythrocytes
** agglutination occurs when this antigen meets serum antibodies<ref name="mikroLF3" />
** TPHA sensitivity in primary syphilis is 69-90%, in secondary syphilis 100% and later around 97%. Specificity is at least 98%<ref name="medmicro">http://www.medmicro.info/portal/syfilis/lvl3/ch09s05.html</ref>
* '''FTA-ABS''' IgG, IgM (fluorescent treponemal antibody – absorbed)
** allows diagnosis from the 2nd to the 3rd week of syphilis
** the antigen is Nichols strain T. pallidum
** a so-called sorbent is used to remove cross-reactive antibodies from the patient's serum
** the patient's antibodies are labeled with a fluorescent dye and fluorescent upon reaction with the antigen
** evaluation of the immunofluorescence response is subjective
** tends to be false positive in systemic lupus erythematosus<ref name="medmicro"/>
* '''ELISA'''
* '''Westernblot''' (WB)
* Previously, Nelson's (-Mayer's) Treponema pallidum immobilization test (TOPIT) and BWR (Bordet-Wasserman reaction) - complement fixation reaction - were used. 

=== Laboratory diagnosis of neurosyphilis ===
* examination of serum and cerebrospinal fluid
* positive treponemal (specific) serological tests (TPHA, ELISA, etc.) are a prerequisite.<ref name="micro"/>
* in [[Liquor|cerebrospinal fluid]] there is [[Cytologické vyšetření mozkomíšního moku#N.C4.9Bkter.C3.A9%20typy%20patologick.C3.BDch%20cytologick.C3.BDch%20n.C3.A1lez.C5.AF%20v%20likvoru|lymphocytic pleocytosis]],  [[Likvorové syndromy|proteinocytological association]], proliferation of immunoglobulins<ref name="Seidel"/>
* positive intrathecal antibody production and TPHA index
* WHO (1982) neurosyphilis criteria: pleocytosis, cardiolipin test positivity (CSF-VDRL) and elevated cerebrospinal fluid protein levels.<ref name="micro"/>
* To rule out neurosyphilis in a patient with positive seroreactions, the negativity of specific cerebrospinal fluid tests is sufficient for me.<ref name="micro">http://www.medmicro.info/portal/syfilis/lvl3/ch05s03.html</ref>

=== Clinical picture ===
* we most often encounter [[cranial nerve]] damage, which is typical for all stages
* '''Argyll-Robertson pupils''' (isocorbic, remarkably broad, non-rounded, do not respond to exposure in a preserved response to convergence) - cause: lesion  [[Nervus oculomotorius|n. III]] or directly mesencephalus
* papillary edema followed by atrophy  [[Nervus opticus|n. II]]  and blindness
* deafness is a consequence of the lesion [[Nervus vestibulocochlearis|n. VIII]]

== Therapy ==
* [[Peniciliny|Penicillin]] is a causal treatment for all stages of the disease
* All forms of syphilis are treatable, the better the results the sooner [[Peniciliny|penicilin]]  is administered
* [[Peniciliny|Penicilin G]] i.v. 2-4 MIU after 4 hours 10-14 days
* [[Peniciliny|Procain penicillin G]]  G i.m. 2-4 MIU (and probenecid 500 mg / 6 h) after 24 hours - a total of 15 days
* Pendepon ([[Peniciliny|benzathine benzylpenicillin]]) i.m. 2-4 MIU every 7 days for 3 weeks
* [[Jarischova-Herxheimerova reakce|Jarisch-Herxheimerova reaction]] - fever and tachycardia at the beginning of treatment, the body's response to endotoxin from decayed spirochetes, responds favorably to corticoid treatment
* in case of hypersensitivity to [[Peniciliny|penicillin]] → p.o. erythromycin or tetracycline for 30 days
* tobacco crisis (see below) will affect  [[Atropin|atropine]] in part<ref name="Seidel"/>

== Acute syphilitic meningitis ==
* The first manifestation of untreated neurolues, has 3 forms:
# '''asymptomatic''' - most, shows only an accidental finding in the cerebrospinal fluid after [[Lumbální punkce|lumbar puncture.]]
# '''aseptic''' - fatigue, [[Meningeální syndrom|meningeal syndrome]], febrile rash
# acute basal - [[Hydrocefalus|hydrocephalus]],  [[Hlavové nervy|cranial nerve]] lesions (n. VII, VIII), papillary edema n. II
* fluid: lymphocytes 100–1000 cells / mm3, increased protein 0.5–2 g / l, sugars decreased, RRR +
* treatment: 1st and 2nd stage - [[Peniciliny|penicillin]]<ref name="Seidel"/>

== Late neurological consequences of untreated syphilis ==
* rare
* in those not treated at the earliest 5 years after the infection during the latency period<ref name="Seidel"/>

=== Meningovascular syphilis (5-10 years) ===
* obliterative endarteritis causes [[Cévní mozkové příhody/PGS|stroke]]
* brain-based granulation causes cranial nerve palsy<ref name="Seidel"/>

=== Spinal syphilis (10-15 years) ===
* the spinal cord is affected by subpiically chronic meningitis
* radicular pain, upper limb muscle atrophy, paraplegia<ref name="Seidel"/>

=== Optical atrophy (in 10-15 years) ===
* chronic meningitis and subpilar necrosis exclusively around n. II bilaterally and bilaterally
* the  narrows
* cerebrospinal fluid is always the same in untreated syphilis with late neurological consequences: lymphocytic pleocytosis 100 / mm3, increased protein and gamma globulins, positive serology
* [[Peniciliny|penicilin]] is the drug of choice<ref name="Seidel"/>

=== Progressive paralysis (in 15-20 years) ===
* '''subacute meningoencephalitis''' with predominantly frontal involvement
* very rare today
* neurastenie → [[poruchy afektivity]] (manie), koncentrace, chování, úsudku a paměti → progresivní [[demence]] – '''''preparalytické stadium'''''
* '''''paralytic stage''''' - + corticospinal, extrapyramidal, myoclonus, or [[Argyll-Robertsonova zornice|Argyll-Robertson pupil]], dysarthria, [[Epilepsie|epilepsy]] → ends with personality breakdown and general marasmus, sudden death - ictus paralyticus
* most often - megalomaniac form - giant delusions, depressive form, simplex form - picture of progressing dementia, Lissauer form - neurological symptomatology, cerebrospinal fluid paralysis - cerebrospinal fluid finding, without clinical manifestation
* dg: seropositivity - treponemal reactions (TPHA, TPI)
* fluid: lymphocytic pleocytosis 50 / mm3, protein 0.5–2 g / l, gamma globulins +++, RRR +
* autopsy: brain atrophy. cortex, diaper thickening, lymphocyte and plasma cell infiltrates around blood vessels, microglia proliferation, neuronal degeneration
* [[Peniciliny|penicillin]] stops progression in 40% of patients (formerly Wagner-Jauregg - malariotherapy)<ref name="Seidel"/>

=== Tabes dorsalis (in 15-20 years) ===
* '''atrophy of the posterior cords and spinal roots'''
* Inflammation occurs on the spinal cord as chronic progressive [[meningitis]] 
* very rare
* it also affects the optic nerves (20% have papillary [[Atrofie|atrophy]])
* [[Ataxie|ataxia]], imbalances, hyporeflexia (up to patellar and Achilles tendon areflexia), lanceic lower limb pain, trophic and pupil changes (90% miotic unresponsive to exposure, positive Romberg symptom
* '''tobacco crises''' = visceral colic that faithfully mimics a sudden abdominal event - pain, nausea, vomiting, tenezms, diarrhea
* bouts of burning paresthesias often affect the  [[N. ischiadicus|sciatic nerve]] and the  [[N. ulnaris|ulnar nerve.]]
* incontinence, impotence, genital numbness
* painless joint deformities, trophic ulcers on the leg (malum perforans) are the result of trauma from a lack of [[Propriocepce|proprioception]], with no hope of improvement
* cerebrospinal fluid is closer to normal than in progressive paralysis, IgG, lymphocytic pleocytosis to several dozen elements is increased. moderate hyperproteinosis, RRR is up to 30% negative
* syphilitic gum is extremely rare, as infiltrative limited inflammation affects not only the brain but also other organs, such as the liver<ref name="Seidel"/>

== Bone syphilis ==
* rare
* '''adrenal syphilis:''' [[osteochodritis]] growth plates of long bones, reactive [[periostitis]] (bone line doubling)
* acquired syphilis: negumous periostitis with [[Lebka|skull]] and [[Tibie|tibia]] involvement / gummy syphilitic periostitis and destructive [[osteomyelitis]](defects in the skull, perforation of the  [[Oral cavity|palate]], compression fractures of the   [[Obratle|vertebrae]])<ref name="Povýšil">{{Cite|type = book |surname1 = POVÝŠIL|name1 = Ctibor|surname2 = ŠTEINER|name2 = Ivo|others = yes|title = Speciální patologie|edition = 2.|location = Praha|publisher = Galén-Karolinum|year = 2007|pages = 297-299|isbn = 978-80-7262-494-2 }}</ref>

<noinclude>

== Links ==
=== Related articles ===
* [[Vrozená syfilis|Congenital syphilis]]
* [[Tabes dorsalis (preparát)|Tabes dorsalis (preparation)]]
=== External links ===
* [[wikipedia:cs:Syfilis|Syfilis (czech wikipedia)]]
* [[wikipedia:en:Syphilis|Syphilis (english wikipedia)]]

=== Sources ===
<references/>

=== Use literature ===
* {{Cite
|type = book
|surname1 = SEIDL
|name1 = Zdeněk
|surname2 = OBENBERGER
|name2 = Jiří
|company = no
|title = Neurologie pro studium i praxi
|edition = 1
|location = Praha
|publisher = Grada Publishing
|year = 2004
|isbn = 80-247-0623-7
}}
* {{Cite
|type = book
|surname1 = POVÝŠIL
|name1 = Ctibor
|surname2 = ŠTEINER
|name2 = Ivo
|others = yes
|title = Speciální patologie
|edition = 2.
|location = Praha
|publisher = Galén-Karolinum
|year = 2007
|pages = 297-299
|isbn = 978-80-7262-494-2 
}}
* {{Cite
|type = book
|surname1 = DOSTÁL
|name1 = Václav
|others = yes
|title = Infektologie
|edition = 1
|location = Praha
|publisher = Karolinum
|year = 2005
|isbn = 80-246-0749-2
}}
* {{Cite
| type = book
| surname1 = Nevšímalová
| jméno1 = Soňa
| surname2 = Růžička
| name2 = Evžen
| surname3 = Tichý
| name3 = Jiří
| title = Neurologie
| edition = 1
| location = Praha
| publisher = Galén
| year = 2002
| isbn = 80-7262-160-2
}}
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</noinclude>

[[Category:Neurology]]
[[Category:Microbiology]]
[[Category:Dermatovenerology]]
[[Category:Infectious diseases]]
[[Category:Pathology]]