Carbetocin
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Carbetocin is a derivative of oxytocin used in obstetrics to prevent uterine atony and postpartum hemorrhage after caesarean section with epidural or spinal anesthesia.< ref name=SPC/>
Mechanism of action[edit | edit source]
Carbetocin is an agonist of peripheral oxytocin receptors but is 50% more potent than endogenous or exogenous oxytocin.[1]
Carbetocin also inhibits the release of endogenous oxytocin. It inhibits feedback from the uterus to the hypothalamus and thus blocks central oxytocin. Carbetocin has no effect on the uterus outside of pregnancy because oxytocin receptors are not present.[2]
Contraindications[edit | edit source]
Carbetocin must not be used for labor induction, during pregnancy, in case of preeclampsia or eclampsia and severe cardiovascular diseases.
Links[edit | edit source]
Related Articles[edit | edit source]
References[edit | edit source]
- ↑ ENGSTRØM, T – BARTH, T – MELIN, P. , et al. Oxytocin receptor binding and uterotonic activity of carbetocin and its metabolites following enzymatic degradation. Eur J Pharmacol [online]. 1998, vol. 355, no. 2-3, p. 203-10, Available from <https://www.ncbi.nlm.nih.gov/pubmed/9760035>. ISSN 0014-2999.
- ↑ MOERTL, M G – FRIEDRICH, S – KRASCHL, J. , et al. Haemodynamic effects of carbetocin and oxytocin given as intravenous bolus on women undergoing caesarean delivery: a randomized trial. BJOG [online]. 2011, vol. 118, no. 11, p. 1349-56, Available from <https://www.ncbi.nlm.nih.gov/pubmed/21668768>. ISSN 1470-0328 (print), 1471-0528.
