Congenic Strain: Difference between revisions
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Congenic strains are special type of strains where a specific and defined part of the [[genome]] from one inbred strain (strain A) is introgressed on the genetic background of second inbred strain (strain B). The congenic strain is an inbred strain, so it is homozygous throughout the whole [[genome]], the only difference between strain B and congenic strain B.A# (where # is a specific number of the [[chromosome]]) is just the "differential" segment of [[chromosome]] #. If strain B and congenic strain B.A# differ in any [[phenotype]] (body weight, glycemia, or sensitivity to [[teratogen]]), it can be assumed that within the differential segment there is a [[gene]] or there are genes responsible for genetic determination of the studied [[phenotype]]. Special types of congenic strains include [[Consomic Strain|consomic | Congenic strains are special type of strains where a specific and defined part of the [[genome]] from one inbred strain (strain A) is introgressed on the genetic background of second inbred strain (strain B). The congenic strain is an inbred strain, so it is homozygous throughout the whole [[genome]], the only difference between strain B and congenic strain B.A# (where # is a specific number of the [[chromosome]]) is just the "differential" segment of [[chromosome]] #. If strain B and congenic strain B.A# differ in any [[phenotype]] (body weight, glycemia, or sensitivity to [[teratogen]]), it can be assumed that within the differential segment there is a [[gene]] or there are genes responsible for genetic determination of the studied [[phenotype]]. Special types of congenic strains include [[Consomic Strain|consomic strains]] and [[conplastic strain]]s. | ||
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Revision as of 18:21, 8 December 2014
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This article ws checked by pedagogue, but later was changed. Checked version of the article can be found here. |
| English: congenic strain Czech: kongenní kmen |
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Congenic strains are special type of strains where a specific and defined part of the genome from one inbred strain (strain A) is introgressed on the genetic background of second inbred strain (strain B). The congenic strain is an inbred strain, so it is homozygous throughout the whole genome, the only difference between strain B and congenic strain B.A# (where # is a specific number of the chromosome) is just the "differential" segment of chromosome #. If strain B and congenic strain B.A# differ in any phenotype (body weight, glycemia, or sensitivity to teratogen), it can be assumed that within the differential segment there is a gene or there are genes responsible for genetic determination of the studied phenotype. Special types of congenic strains include consomic strains and conplastic strains.
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Bibliography
- ŠEDA, Ondřej – LIŠKA, František – ŠEDOVÁ, Lucie. Current genetics [online]. ©2005-2006. [cit. 2011-09-08]. <http://biol.lf1.cuni.cz/ucebnice/en/index.htm>.
