Poststreptococcal Acute Glomerulonephritis: Difference between revisions
From WikiLectures
m (→Links) |
|||
| (4 intermediate revisions by 4 users not shown) | |||
| Line 1: | Line 1: | ||
__TOC__ | __TOC__ | ||
'''PSAGN is the | '''PSAGN is the most common form of immune mediated inflammation of glomerules in childhood. It is caused by ''Streptococcus pyogenes'' infection.''' | ||
== Epidemiology and | == Epidemiology and Etiology == | ||
Typical '''age is 2-12 years'''. Patients usually have | Typical '''age is 2-12 years'''. Patients usually have streptococcal '''pharyngitis or impetigo 5-21 days before''' PSAGN manifestation. Incidence is 6–20:100 000 in western countries (usually sporadic occurrence), in developing countries even higher because of '''lower hygienic standard''' and '''malnutrition''' (epidemic occurrence). Other risk factors are: | ||
* gender (more frequent in '''boys'''); | * gender (more frequent in '''boys'''); | ||
* even '''genetic predisposition''' for PSAGN. | * even '''genetic predisposition''' for PSAGN. | ||
| Line 10: | Line 10: | ||
== Pathophysiology == | == Pathophysiology == | ||
There are some antigenes produced by ''Streptococcus pyogenes'' the most important is NSAP-streptokinase (nephritogen strains associated protein), M-protein and endostreptosin. These antigenes are binded by specific antibodies. So creaed immunocomplexes are taken up in capillaries of glomerules as deposites. It is mediated by activation of complement too. Finally, it leads to proligerative glomerulonephritis with decreased glomelural filtration, higher natrium resorption in tubules (→ edema), increased renin secretion (→ hypertension). | |||
[[File:Renal corpuscle.svg|thumb|Scheme of normal renal corpuscle.]] | [[File:Renal corpuscle.svg|thumb|Scheme of normal renal corpuscle.]] | ||
[[File:Acute Glomerulonephritis Pathology Diagram.svg|thumb|Scheme of glomerular capillary in PSAGN - immune complex deposits below the podocyte foot processes (black).]] | [[File:Acute Glomerulonephritis Pathology Diagram.svg|thumb|Scheme of glomerular capillary in PSAGN - immune complex deposits below the podocyte foot processes (black).]] | ||
[[File:Post-infectious glomerulonephritis - very high mag.jpg|thumb|PSAGN - histopathology.]] | [[File:Post-infectious glomerulonephritis - very high mag.jpg|thumb|PSAGN - histopathology.]] | ||
== Diagnostic == | == Diagnostic == | ||
=== | === Symptoms<ref>{{Cite | ||
| type = book | | type = book | ||
| surname1 = Kliegman | | surname1 = Kliegman | ||
| Line 29: | Line 29: | ||
}}</ref> === | }}</ref> === | ||
* '''edema''' (75% of patients); | * '''edema''' (75% of patients); | ||
* '''gross hematuria''' (65%) - tea colored or cola | * '''gross hematuria''' (65%) - tea colored or cola colored urine; | ||
* '''hypertension''' (50%); | * '''hypertension''' (50%); | ||
* acute renal insufficiency with oliguria. | * acute renal insufficiency with oliguria. | ||
| Line 39: | Line 39: | ||
=== Diagnostic Methods === | === Diagnostic Methods === | ||
* '''urine examination''' → | * '''urine examination''' → | ||
** | ** [[hematuria]], | ||
** mild to moderate proteinuria, | ** mild to moderate proteinuria, | ||
** concentrated urine (there is oliguria!), | ** concentrated urine (there is oliguria!), | ||
| Line 46: | Line 46: | ||
* '''blood examination''' → | * '''blood examination''' → | ||
** elevated creatinin (based on decreased glomerular filtration), | ** elevated creatinin (based on decreased glomerular filtration), | ||
** | ** ASO antibodies, | ||
** reduced serum C3 level (if it has normal level, it should be different diagnosis), | ** reduced serum C3 level (if it has normal level, it should be different diagnosis), | ||
** elevated serum IgM and IgG | ** elevated serum IgM and IgG | ||
| Line 53: | Line 53: | ||
== Therapy == | == Therapy == | ||
Therapy of PSAGN is based on: | |||
* dietary sodium restriction | * dietary sodium restriction | ||
* diuretics | * diuretics | ||
| Line 92: | Line 92: | ||
</noinclude> | </noinclude> | ||
[[Category:Paediatrics]] | [[Category:Paediatrics]] | ||
[[Category:Nephrology]] | [[Category:Nephrology]] | ||
Latest revision as of 05:36, 18 March 2015
PSAGN is the most common form of immune mediated inflammation of glomerules in childhood. It is caused by Streptococcus pyogenes infection.
Epidemiology and Etiology[edit | edit source]
Typical age is 2-12 years. Patients usually have streptococcal pharyngitis or impetigo 5-21 days before PSAGN manifestation. Incidence is 6–20:100 000 in western countries (usually sporadic occurrence), in developing countries even higher because of lower hygienic standard and malnutrition (epidemic occurrence). Other risk factors are:
- gender (more frequent in boys);
- even genetic predisposition for PSAGN.
Nephritogenic beta-heamolytic streptococcus, group A, type M 12 and 49 ist the most often originator.
Pathophysiology[edit | edit source]
There are some antigenes produced by Streptococcus pyogenes the most important is NSAP-streptokinase (nephritogen strains associated protein), M-protein and endostreptosin. These antigenes are binded by specific antibodies. So creaed immunocomplexes are taken up in capillaries of glomerules as deposites. It is mediated by activation of complement too. Finally, it leads to proligerative glomerulonephritis with decreased glomelural filtration, higher natrium resorption in tubules (→ edema), increased renin secretion (→ hypertension).
Diagnostic[edit | edit source]
Symptoms[1][edit | edit source]
- edema (75% of patients);
- gross hematuria (65%) - tea colored or cola colored urine;
- hypertension (50%);
- acute renal insufficiency with oliguria.
consequences of hypertension, oliguria and renal insufficiency can be"
- heart failure;
- encephalopathy.
Diagnostic Methods[edit | edit source]
- urine examination →
- hematuria,
- mild to moderate proteinuria,
- concentrated urine (there is oliguria!),
- and the presence of casts,
- urine culture is necessary too
- blood examination →
- elevated creatinin (based on decreased glomerular filtration),
- ASO antibodies,
- reduced serum C3 level (if it has normal level, it should be different diagnosis),
- elevated serum IgM and IgG
- ultrasonography of kidneys
- renal biopsy is not indicated! -diagnosis is based on previous streptococcal infection anamnesis and symptomatology (edema, hematuria, hypertension)
Therapy[edit | edit source]
Therapy of PSAGN is based on:
- dietary sodium restriction
- diuretics
- antihypertensive agents.
Complete remission is in 95% of patients, only 5% of all patients can progress to end stage renal disease.
Links[edit | edit source]
Related articles[edit | edit source]
References[edit | edit source]
- ↑ KLIEGMAN, Robert M, et al. Nelson Essentials of Pediatrics. 5th edition. Philadelphia : Elseiver, 2006. pp. 758. ISBN 978-1-4160-0159-1.
Bibliography[edit | edit source]
- KLIEGMAN, Robert M, et al. Nelson Essentials of Pediatrics. 5th edition. Philadelphia : Elseiver, 2006. pp. 757-759. ISBN 978-1-4160-0159-1.
- WikiSkripta. Akutní glomerulonefritida [online]. ©2011. The last revision 2011-10-03, [cit. 2011-12-21]. <http://www.wikiskripta.eu/index.php/Akutn%C3%AD_glomerulonefritida>.
