Congenic Strain: Difference between revisions
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{{Dictionary | {{Dictionary | ||
|eng = congenic strain | |eng = congenic strain | ||
|cze = kongenní kmen | |cze = kongenní kmen | ||
}} | }} | ||
Congenic strains are special type of strains where a specific and defined part of the [[genome]] from one inbred strain (strain A) is introgressed on the genetic background of second inbred strain (strain B). The congenic strain is an inbred strain, so it is homozygous throughout the whole [[genome]], the only difference between strain B and congenic strain B.A# (where # is a specific number of the [[chromosome]]) is just the "differential" segment of [[chromosome]] #. If strain B and congenic strain B.A# differ in any [[phenotype]] (body weight, glycemia, or sensitivity to [[teratogen]]), it can be assumed that within the differential segment there is a [[gene]] or there are genes responsible for genetic determination of the studied [[phenotype]]. Special types of congenic strains include [[Consomic Strain|consomic | Congenic strains are special type of strains where a specific and defined part of the [[genome]] from one inbred strain (strain A) is introgressed on the genetic background of second inbred strain (strain B). The congenic strain is an inbred strain, so it is homozygous throughout the whole [[genome]], the only difference between strain B and congenic strain B.A# (where # is a specific number of the [[chromosome]]) is just the "differential" segment of [[chromosome]] #. If strain B and congenic strain B.A# differ in any [[phenotype]] (body weight, glycemia, or sensitivity to [[teratogen]]), it can be assumed that within the differential segment there is a [[gene]] or there are genes responsible for genetic determination of the studied [[phenotype]]. Special types of congenic strains include [[Consomic Strain|consomic strains]] and [[conplastic strain]]s. | ||
[[File:CONGENIC STRAIN.png|600px]] | [[File:CONGENIC STRAIN.png|600px]] | ||
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[[Category:Genetics]] | [[Category:Genetics]] | ||
Latest revision as of 14:20, 15 September 2015
| English: congenic strain Czech: kongenní kmen |
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Congenic strains are special type of strains where a specific and defined part of the genome from one inbred strain (strain A) is introgressed on the genetic background of second inbred strain (strain B). The congenic strain is an inbred strain, so it is homozygous throughout the whole genome, the only difference between strain B and congenic strain B.A# (where # is a specific number of the chromosome) is just the "differential" segment of chromosome #. If strain B and congenic strain B.A# differ in any phenotype (body weight, glycemia, or sensitivity to teratogen), it can be assumed that within the differential segment there is a gene or there are genes responsible for genetic determination of the studied phenotype. Special types of congenic strains include consomic strains and conplastic strains.
Links[edit | edit source]
Related articles[edit | edit source]
Bibliography[edit | edit source]
- ŠEDA, Ondřej – LIŠKA, František – ŠEDOVÁ, Lucie. Current genetics [online]. ©2005-2006. [cit. 2011-09-08]. <http://biol.lf1.cuni.cz/ucebnice/en/index.htm>.
