Long QT syndrome: Difference between revisions
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It is a '''genetic arrhythmogenic disease''', which is characterized by QT prolongation in the absence of structural damage to the [[heart]]. Women are more often affected by this disease. | |||
* '''LQTS''' (''long QT syndrome'') | * '''LQTS''' (''long QT syndrome'') is caused by [[mutation|mutation]] in [[gene]] encoding individual subunits of the [[ion channels|ion channels]] of the heart muscle. Failure of the ion channels results in impaired myocardial repolarization, which affects the [[electrocardiography|EKG]] by prolonging the QT interval. | ||
The risk of LQTS lies in the increased risk of [[malignant]] [[Heart rhythm disorders|arrhythmias]] (especially ventricular tachycardia such as ''torsade de pointes'' or [[ventricular fibrillation]]) and [[sudden cardiad death]].<ref name="">{{Citace | |||
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We distinguish 2 basic forms of LQTS:<ref name="Aschermann"> | |||
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# ''' | # '''Roman-Ward syndrome''' (RWS): [[Autosomal dominant inheritance in pedigree and experiment, examples of traits in man|AD]] inherited form, contains a set of 6 different molecular genotypes. | ||
# ''' | # '''Jervell-Lange-Nielsen syndrome''' (JLNS): The [[AR]] inherited form associated with congenital deafness, contains 2 different molecular genotypes. | ||
LQTS treatment includes '''[[Beta-blockers]]''', '''pacing''', or '''implantation''' [[Implantable cardioverter-defibrillator|'''ICD''']]. | |||
[[Soubor:LQT.png|thumb|800px|center|Nejznámější formy LQTS]] | [[Soubor:LQT.png|thumb|800px|center|Nejznámější formy LQTS]] | ||
== | == References == | ||
=== | === Related articles === | ||
* [[ | * [[Brugada syndrome]] | ||
* [[ | * [[Ventricular fibrillation]] | ||
* [[ | * [[Sudden cardiac death]] | ||
=== Externí odkazy === | === Externí odkazy === | ||
* [https://www.techmed.sk/syndrom-dlheho-qt-intervalu/ Syndróm dlhého QT intervalu (TECHmED)] | * [https://www.techmed.sk/syndrom-dlheho-qt-intervalu/ Syndróm dlhého QT intervalu (TECHmED)] | ||
Revision as of 23:24, 1 January 2022
It is a genetic arrhythmogenic disease, which is characterized by QT prolongation in the absence of structural damage to the heart. Women are more often affected by this disease.
- LQTS (long QT syndrome) is caused by mutation in gene encoding individual subunits of the ion channels of the heart muscle. Failure of the ion channels results in impaired myocardial repolarization, which affects the EKG by prolonging the QT interval.
The risk of LQTS lies in the increased risk of malignant arrhythmias (especially ventricular tachycardia such as torsade de pointes or ventricular fibrillation) and sudden cardiad death.[1][2][3]
We distinguish 2 basic forms of LQTS:[3][4]
- Roman-Ward syndrome (RWS): AD inherited form, contains a set of 6 different molecular genotypes.
- Jervell-Lange-Nielsen syndrome (JLNS): The AR inherited form associated with congenital deafness, contains 2 different molecular genotypes.
LQTS treatment includes Beta-blockers, pacing, or implantation ICD.
thumb|800px|center|Nejznámější formy LQTS
References
Related articles
Externí odkazy
Reference
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- ↑
- ↑ Jump up to: a b
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