Strontium ranelate: Difference between revisions
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=== Adverse effects === | === Adverse effects === | ||
The most common adverse effects leading to discontinuation of treatment were nausea and diarrhea, headaches or skin reactions. Very common side effects include musculoskeletal pain. Common ones include cardiovascular disorders ([[TEN|thromboembolism]], [[acute myocardial infarction]]), [[hepatitis|hepatitis]], bronchial hyperreactivity,[[vertigo]] and others. | The most common adverse effects leading to discontinuation of treatment were nausea and diarrhea, headaches or skin reactions. Very common side effects include musculoskeletal pain. Common ones include cardiovascular disorders ([[TEN|thromboembolism]], [[acute myocardial infarction]]), [[hepatitis|hepatitis]], bronchial hyperreactivity,[[vertigo]] and others. | ||
{{Cave}} | {{Cave}} As of January 2014, the use of strontium renelate is not recommended.<ref>{{Cite | ||
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| surname1 = PRAC | | surname1 = PRAC | ||
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=== Method of administration and dosage === | === Method of administration and dosage === | ||
In the Czech Republic, strontium ranelate is State Drug Control Office: strontium ranelateavailable in sachets for the preparation of an oral suspension. In the treatment of osteoporosis, 2 g of strontium ranelate is administered daily in a single dose (usually at bedtime 2 hours after dinner). The treatment is long-term. | In the Czech Republic, strontium ranelate is State Drug Control Office: strontium ranelateavailable in sachets for the preparation of an oral suspension. In the treatment of osteoporosis, 2 g of strontium ranelate is administered daily in a single dose (usually at bedtime 2 hours after dinner). The treatment is long-term. | ||
== Links == | == Links == | ||
=== Related Articles === | === Related Articles === | ||
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=== External references === | === External references === | ||
* [https://www.sukl.cz/stroncium-ranelat-protelos-pozastaveni-pouzivani Restrictions in administration of strontium ranelate from SÚKL] | * [https://www.sukl.cz/stroncium-ranelat-protelos-pozastaveni-pouzivani Restrictions in administration of strontium ranelate from SÚKL] | ||
[[Category:Pharmacology]] | [[Category:Pharmacology]] | ||
Revision as of 19:38, 7 January 2023
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Stroncium-ranelate is used in medicine as an anti-osteoporotic agent , which has a dual mechanism of action on bone – it increases bone formation and at the same time reduces bone osteoresorption. It is also effective in the elderly and in clinically risky situations (e.g. in the case of bone fragility syndrome). The strontium ranelate molecule contains two Sr 2+ ions bound to an organic carrier – ranelic acid.
Indication
Long-term treatment reducing the risk of vertebral and non-vertebral fractures or fractures of the proximal femur in complicated osteoporosis . The treatment is primarily intended for the treatment of osteoporosis in women after menopause and for the treatment of osteoporosis in men with an increased risk of fractures.
Contraindications
Venous thromboembolism (also in the anamnesis), cardiovascular diseases (ischemic heart disease, strokes, arterial hypertension, diseases of peripheral arteries).
Interactions
The bioavailability of strontium ranelate is reduced by the simultaneous administration of milk, milk products and preparations containing calcium, as well as some antacids. On the other hand, strontium ranelate reduces the absorption of tetracycline and quinolone antibiotics. Simultaneous administration of bisfosphonates or raloxifeneis considered inappropriate.
Adverse effects
The most common adverse effects leading to discontinuation of treatment were nausea and diarrhea, headaches or skin reactions. Very common side effects include musculoskeletal pain. Common ones include cardiovascular disorders (thromboembolism, acute myocardial infarction), hepatitis, bronchial hyperreactivity,vertigo and others.
As of January 2014, the use of strontium renelate is not recommended.[1]
Method of administration and dosage
In the Czech Republic, strontium ranelate is State Drug Control Office: strontium ranelateavailable in sachets for the preparation of an oral suspension. In the treatment of osteoporosis, 2 g of strontium ranelate is administered daily in a single dose (usually at bedtime 2 hours after dinner). The treatment is long-term.
Links
Related Articles
Bibliography
- OLEJÁROVÁ, Marta. Revmatologie v kostce. 1. edition. Praha : Triton, 2008. 231 pp. ISBN 978-80-7387-115-4.
- Státní ústav pro kontrolu léčiv. Stroncium-ranelát (Protelos) – registrace zůstává platná s dalším omezením používání [online]. ©2014. The last revision 2014-02-27, [cit. 2015-03-18]. <https://www.sukl.cz/stroncium-ranelat-protelos-registrace-zustava-platna-s>.
- BERNABEI, Roberto – MARTONE, Anna Maria – ORTOLANI, Elena. , et al. Screening, diagnosis and treatment of osteoporosis: a brief review. Clin Cases Miner Bone Metab [online]. 2014, vol. 11, no. 3, p. 201-7, Available from <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4269144/?tool=pubmed>. ISSN 1724-8914.
- REGINSTER, Jean-Yves. Cardiac concerns associated with strontium ranelate. Expert Opin Drug Saf [online]. 2014, vol. 13, no. 9, p. 1209-13, Available from <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4196504/?tool=pubmed>. ISSN 1474-0338 (print), 1744-764X.
Reference
- ↑ Incomplete citation of web. PRAC,. [cit. 2016-03-16]. <https://www.ema.europa.eu/ema/index.jsp?curl=pages/news_and_events/news/2014/02/news_detail_002031.jsp&mid=WC0b01ac058004d5c1>.
