Ferritin: Difference between revisions
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[[File: Ferritin.png | Ferritin | [[File: Ferritin.png | thumb | Ferritin]] | ||
"Ferritin" is a storage protein containing [[iron]], which is found mainly in the liver, [[spleen | spleen]], bone marrow and intestinal mucosa. A small proportion is released into the bloodstream. The level of ferritin in the blood serum reflects the tissue stores of iron. Its value decreases before the level of [[transferrin]] u increases. <ref> {{ | "Ferritin" is a storage protein containing [[iron]], which is found mainly in the liver, [[spleen | spleen]], bone marrow and intestinal mucosa. A small proportion is released into the bloodstream. The level of ferritin in the blood serum reflects the tissue stores of iron. Its value decreases before the level of [[transferrin]] u increases. <ref> {{Cite | type = book | isbn = 80-7262-023-1 | surname1 = Seagull | name1 = J | others = yes | title = Clinical Biochemistry | edition = 1 | location = Prague | publisher = Galén - Karolinum | year = 1999 | pages = 64}} </ref> | ||
It is a complex consisting of the protein [[apoferritin]] em and the ferric iron Fe <sup> 3+ </sup>. <ref> {{ | It is a complex consisting of the protein [[apoferritin]] em and the ferric iron Fe <sup> 3+ </sup>. <ref> {{Cite | type = web | surname1 = Švíglerová | name1 = Jitka | url = https: //web.archive.org/web/20160416225121/http: //wiki.lfp-studium.cz/index.php/Feritin | source_name = Ferritin | date_of_revision = 2009-02-18 | cited = 2010-11-13}} </ref> | ||
=== Normal values of ferritin === | === Normal values of ferritin === | ||
* Males: 22 - 322 μg / l | * Males: 22 - 322 μg / l | ||
* Women: 10 - 291 μg / l <ref> {{ | * Women: 10 - 291 μg / l <ref> {{Cite | type = book| surname1 = Vokurka | name1 = Martin | title = Great Medical Dictionary| edition = 10 | publisher = Maxdorf | year = 2015 | isbn = 9788073454562}} </ref> | ||
=== High level | === High Iron level === | ||
* [[Hemochromatosis]], | * [[Hemochromatosis]], | ||
* [[Wilson's disease]], | * [[Wilson's disease]], | ||
* | * Blood transfusion, | ||
* | * Excessive iron intake in the diet, | ||
* [[ | * [[Porphyria cutanea tarda]], | ||
* | * Ineffective erythropoiesis ([[sideroblastic anemia]], [[thalassemia]]). | ||
=== Inflammation === | === Inflammation === | ||
Ferritin is one of the [[acute phase reactants]] | Ferritin is one of the [[acute phase reactants]] | ||
| Line 28: | Line 29: | ||
* viral hepatitis B, C; | * viral hepatitis B, C; | ||
=== Other causes === | === Other causes === | ||
Obesity, alcohol abuse, thyrotoxicosis and malignancies, especially haematological <ref> {{ | Obesity, alcohol abuse, thyrotoxicosis and malignancies, especially haematological <ref> {{Cite | type = article | surname1 = Berkhan | name1 = L | article = Interpretation of an elevated serum ferritin| journal = nzfp | url = http://www.rnzcgp.org.nz/AsiCommon/Controls/Shared/FormsAuthentication/Login.aspx?ReturnUrl=%2fassets%2fdocuments%2fPublications%2fArchive-NZFP%2fFeb-2002-NZFP-Vol-29-No -1% 2fberkhan.pdf | year = 2002 | volume = 29 | pages = 45-48 | issn = -}} </ref> | ||
Rarely, extremely high levels of ferritin can be a symptom of [[histiocytosis | histiocytosis]] or [[Still's disease | Still's disease]]. <ref> {{ | Rarely, extremely high levels of ferritin can be a symptom of [[histiocytosis | histiocytosis]] or [[Still's disease | Still's disease]]. <ref> {{Cite | type = article| surname1 = Adams | name1 = Paul | article = Management of Elevated Serum Ferritin Levels | journal = Gastroenterology and hepatology | url = https: //www.ncbi.nlm.nih.gov/pmc/articles/PMC3093720/ | year = 2008 | year = - | volume = - | pages = 333-334 | issn = -}} </ref> | ||
<noinclude> | <noinclude> | ||
== Links == | == Links == | ||
=== External links === | === External links === | ||
* [[wikipedia: cs: Feritin | Feritin (česká wikipedie)]] | * [[wikipedia:cs:Feritin|Feritin (česká wikipedie)]] | ||
* [https://www.youtube.com/watch?v=NvNINrtE39g Iron Storage: Ferritin (YouTube)] | * [https://www.youtube.com/watch?v=NvNINrtE39g Iron Storage: Ferritin (YouTube)] | ||
=== | === References === | ||
<references /> | <references /> | ||
</noinclude> | </noinclude> | ||
Latest revision as of 01:21, 17 January 2024
"Ferritin" is a storage protein containing iron, which is found mainly in the liver, spleen, bone marrow and intestinal mucosa. A small proportion is released into the bloodstream. The level of ferritin in the blood serum reflects the tissue stores of iron. Its value decreases before the level of transferrin u increases. [1]
It is a complex consisting of the protein apoferritin em and the ferric iron Fe 3+ . [2]
Normal values of ferritin[edit | edit source]
- Males: 22 - 322 μg / l
- Women: 10 - 291 μg / l [3]
High Iron level[edit | edit source]
- Hemochromatosis,
- Wilson's disease,
- Blood transfusion,
- Excessive iron intake in the diet,
- Porphyria cutanea tarda,
- Ineffective erythropoiesis (sideroblastic anemia, thalassemia).
Inflammation[edit | edit source]
Ferritin is one of the acute phase reactants
- Rheumatoid arthritis,
- SLE,
- non-specific intestinal inflammation,
- bacterial infections;
Liver disease[edit | edit source]
Ferritin is stored mainly in hepatocytes, when they are damaged it is released into the blood.
- liver steatosis (NASH),
- viral hepatitis B, C;
Other causes[edit | edit source]
Obesity, alcohol abuse, thyrotoxicosis and malignancies, especially haematological [4] Rarely, extremely high levels of ferritin can be a symptom of histiocytosis or Still's disease. [5]
Links[edit | edit source]
External links[edit | edit source]
References[edit | edit source]
- ↑ SEAGULL, J, et al. Clinical Biochemistry. 1. edition. Prague : Galén - Karolinum, 1999. pp. 64. ISBN 80-7262-023-1.
- ↑ ŠVÍGLEROVÁ, Jitka. Ferritin [online]. The last revision 2009-02-18, [cit. 2010-11-13]. <https: //web.archive.org/web/20160416225121/http: //wiki.lfp-studium.cz/index.php/Feritin>.
- ↑ VOKURKA, Martin. Great Medical Dictionary. 10. edition. Maxdorf, 2015. ISBN 9788073454562.
- ↑ BERKHAN, L. Interpretation of an elevated serum ferritin. nzfp [online]. 2002, vol. 29, p. 45-48, Available from <http://www.rnzcgp.org.nz/AsiCommon/Controls/Shared/FormsAuthentication/Login.aspx?ReturnUrl=%2fassets%2fdocuments%2fPublications%2fArchive-NZFP%2fFeb-2002-NZFP-Vol-29-No -1% 2fberkhan.pdf>.
- ↑ ADAMS, Paul. Management of Elevated Serum Ferritin Levels. Gastroenterology and hepatology [online]. -, vol. -, p. 333-334, Available from <https: //www.ncbi.nlm.nih.gov/pmc/articles/PMC3093720/>.
