Acetylsalicylic acid: Difference between revisions
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'''Acetylsalicylic acid''' (ASA) or more commonly known as '''aspirin''' is a nonsteroidal anti-inflammatory drug (NSAID, NSA) used as an analgetic, antipyretic, antiphlogistic (anti-inflammatory) and antithrombotic drug. It is therefore used to treat pain, fever, inflammation, but also has the potential to reduce major adverse cardiovascular events by inhibiting platelet aggregation - preventing blood clot formation which could lead to stroke or myocardial infarction (MI). | '''Acetylsalicylic acid''' (ASA) or more commonly known as '''aspirin''' is a nonsteroidal anti-inflammatory drug (NSAID, NSA) used as an analgetic, antipyretic, antiphlogistic (anti-inflammatory) and antithrombotic drug. It is therefore used to treat pain, fever, inflammation, but also has the potential to reduce major adverse cardiovascular events by inhibiting platelet aggregation - preventing blood clot formation which could lead to stroke or myocardial infarction (MI). <ref> | ||
{{Cite | |||
| type = web | |||
| corporation = National Center for Biotechnology Information | |||
| source_name = PubChem Compound Summary for CID 2244, Aspirin | |||
| publisher = National Library of Medicine | |||
| cited = 2022-11-13 | |||
| url = https://pubchem.ncbi.nlm.nih.gov/compound/Aspirin | |||
}} </ref> | |||
Chemically, acetylsalicylic acid is a derivative of salicylic acid, which belongs to aromatic hydroxy acids. It '''irreversibly inhibits''' (by means of acetylation) the enzyme '''''cyclooxygenase (COX)''''' both type 1 and 2 but has a greater affinity to COX-1. COX-1 is a consitutional enzyme, while COX-2 is | Chemically, acetylsalicylic acid is a derivative of salicylic acid, which belongs to aromatic hydroxy acids. It '''irreversibly inhibits''' (by means of acetylation) the enzyme '''''cyclooxygenase (COX)''''' both type 1 and 2 but has a greater affinity to COX-1. COX-1 is a consitutional enzyme, while COX-2 is | ||
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*[[wikipedia:en:Aspirin|Aspirin (anglická wikipedie)]] | *[[wikipedia:en:Aspirin|Aspirin (anglická wikipedie)]] | ||
===Použitá literatura=== | ===Použitá literatura=== | ||
*{{ | *{{Cite | ||
| | | type = book | ||
| | | surname1 = Ledvina | ||
| | | name1 = Miroslav | ||
| | | others = yes | ||
| | | title = Biochemie pro studující medicíny I. díl | ||
| | | edition = 2 | ||
| | | city = Prague | ||
| | | publisher = Nakladatelství Karolinum | ||
| | | year = 2009 | ||
| | | range = 269 | ||
| isbn = 978-80-246-1416-8 | | isbn = 978-80-246-1416-8 | ||
}} | }} | ||
*{{ | *{{CiCitetace | ||
| | | type = book | ||
| isbn = 978-80-7262-373-0 | | isbn = 978-80-7262-373-0 | ||
| | | surname1 = Lincová | ||
| | | name1 = Dagmar | ||
| | | surname2 = Farghali | ||
| | | name2 = Hassan | ||
| | | others = yes | ||
| | | title = Základní a aplikovaná farmakologie | ||
| | | edition = 2 | ||
| | | city = Prague | ||
| | | publisher = Galén | ||
| | | year = 2007 | ||
| | | range = 672 | ||
}} | }} | ||
{{ | {{Cite | ||
| | | type = book | ||
| | | surname1 = Lüllmann | ||
| | | name1 = Heinz | ||
| | | surname2 = Mohr | ||
| | | name2 = Klaus | ||
| | | surname3 = Wehling | ||
| | | name3 = Martin | ||
| | | title = Farmakologie a toxikologie | ||
| | | subtitle = 47 tabulek | ||
| | | edition = - | ||
| | | publisher = Grada Publishing a.s. | ||
| | | year = 2002 | ||
| isbn = 80-7169-976-4 | | isbn = 80-7169-976-4 | ||
| | | range = 696 | ||
| | | pages = 330 | ||
}} </noinclude>[[ | }} </noinclude>[[Category:Farmacology]] [[Category:Biochemistry]] | ||
Revision as of 13:51, 13 November 2022
Acetylsalicylic acid (ASA) or more commonly known as aspirin is a nonsteroidal anti-inflammatory drug (NSAID, NSA) used as an analgetic, antipyretic, antiphlogistic (anti-inflammatory) and antithrombotic drug. It is therefore used to treat pain, fever, inflammation, but also has the potential to reduce major adverse cardiovascular events by inhibiting platelet aggregation - preventing blood clot formation which could lead to stroke or myocardial infarction (MI). [1]
Chemically, acetylsalicylic acid is a derivative of salicylic acid, which belongs to aromatic hydroxy acids. It irreversibly inhibits (by means of acetylation) the enzyme cyclooxygenase (COX) both type 1 and 2 but has a greater affinity to COX-1. COX-1 is a consitutional enzyme, while COX-2 is
Kyselina acetylsalicylová je derivátem kyseliny salicylové (ta patří mezi aromatické hydroxykyseliny). Ireverzibilně inhibuje enzym cyklooxygenázu (COX), s větší tendencí k inhibici COX-1 (konstituční enzym) oproti COX-2 (indubicilní enzym). Tato schopnost inhibice je přisuzována labilní, esterově vázané acetátové skupině. Kyselina acetylsalicylová takto tedy blokuje cyklizační cestu přeměny kyseliny arachidonové a brání následovně tvorbě eikosanoidů.
Působí jako analgetikum, antipyretikum, antiflogistikum a antitrombotikum (má protidestičkové účinky). Je součástí léčiv jako je Acylpyrin® či Aspirin® a patří mezi nejrozšířenější léky.
Giving aspirin to children under 12 years of age is contraindicayed due to potential
Kyselinu acetylsalicylovou nepodáváme dětem do 12 let kvůli možnému vzniku Reyeova syndromu.
Odkazy
Související články
Externí odkazy
Použitá literatura
- LEDVINA, Miroslav, et al. Biochemie pro studující medicíny I. díl. 2. edition. Nakladatelství Karolinum, 2009. 269 pp. ISBN 978-80-246-1416-8.
LÜLLMANN, Heinz – MOHR, Klaus – WEHLING, Martin. Farmakologie a toxikologie : 47 tabulek. - edition. Grada Publishing a.s., 2002. 696 pp. pp. 330. ISBN 80-7169-976-4.
- ↑ National Center for Biotechnology Information. PubChem Compound Summary for CID 2244, Aspirin [online]. National Library of Medicine, [cit. 2022-11-13]. <https://pubchem.ncbi.nlm.nih.gov/compound/Aspirin>.
