Liposomes as drug carriers: Difference between revisions
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== Liposomes as a drug delivery system == | == Liposomes as a drug delivery system == | ||
Liposomes are microscopic spherical vesicles. These vesicles have a great impact when it comes to the field of medicine. Liposomes have been used as a way of delivering drugs, which could possibly make it the way of the future. However, there are some risks that may prevent it from achieving that potential. | Liposomes are microscopic spherical vesicles. These vesicles have a great impact when it comes to the field of medicine. Liposomes have been used as a way of delivering drugs, which could possibly make it the way of the future. However, there are some risks that may prevent it from achieving that potential. | ||
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=== Basic structure === | === Basic structure === | ||
[[File:Cholesterol-in-phospholipids.gif|thumb|Cholesterol in a conventional liposome]] | |||
The outer part of a liposome, the membrane, is composed of a phospholipid bilayer enclosing in an aqueous volume. Phospholipids are the main building block of liposomes. They have tubular shape and two acyl chains attached to a polar head, which with hydration results in a bilayer, with a hydrophilic head and two hydrophobic tails. This combination means that liposomes are amphiphilic. Liposomes can either be naturally derived phospholipids or of pure surfactant components like DOPE. | The outer part of a liposome, the membrane, is composed of a phospholipid bilayer enclosing in an aqueous volume. Phospholipids are the main building block of liposomes. They have tubular shape and two acyl chains attached to a polar head, which with hydration results in a bilayer, with a hydrophilic head and two hydrophobic tails. This combination means that liposomes are amphiphilic. Liposomes can either be naturally derived phospholipids or of pure surfactant components like DOPE. | ||
Cholesterol is important for liposomes as it’s used as a membrane additive to fill up the empty spaces between the phospholipids. Cholesterol increases the fluidity of the cell’s membrane and provides an increase in the order of the bilayer as it anchors the components of the bilayer more strongly. This increases the transition temperature of the system and provides stability. | Cholesterol is important for liposomes as it’s used as a membrane additive to fill up the empty spaces between the phospholipids. Cholesterol increases the fluidity of the cell’s membrane and provides an increase in the order of the bilayer as it anchors the components of the bilayer more strongly. This increases the transition temperature of the system and provides stability. | ||
[[File:Where-drugs-are-liposome.jpg|thumb|Hydrophobic and hydrophilic drug placement inside the liposome]] | [[File:Where-drugs-are-liposome.jpg|thumb|Hydrophobic and hydrophilic drug placement inside the liposome|278x278px]] | ||
Revision as of 13:26, 7 December 2015
Liposomes as a drug delivery system
Liposomes are microscopic spherical vesicles. These vesicles have a great impact when it comes to the field of medicine. Liposomes have been used as a way of delivering drugs, which could possibly make it the way of the future. However, there are some risks that may prevent it from achieving that potential.
A liposome containing a certain drug, or genetic material, can be delivered past the cellular lipid bilayer by fusing with the cell’s bilayer. To do this both membranes need to come in very close contact of each other. The liposome fuses with the outer layer of the plasma membrane, then the two fused membranes unite as the inner layers of both membranes get closer to each other as the drug is delivered as both layers fuse.
Basic structure
The outer part of a liposome, the membrane, is composed of a phospholipid bilayer enclosing in an aqueous volume. Phospholipids are the main building block of liposomes. They have tubular shape and two acyl chains attached to a polar head, which with hydration results in a bilayer, with a hydrophilic head and two hydrophobic tails. This combination means that liposomes are amphiphilic. Liposomes can either be naturally derived phospholipids or of pure surfactant components like DOPE.
Cholesterol is important for liposomes as it’s used as a membrane additive to fill up the empty spaces between the phospholipids. Cholesterol increases the fluidity of the cell’s membrane and provides an increase in the order of the bilayer as it anchors the components of the bilayer more strongly. This increases the transition temperature of the system and provides stability.
