C-reactive protein
C-reactive protein (CRP)' is one of the most important acute phase reactants. It is a protein that plays the role of opsoninu. It got its name due to the fact that it precipitates with the so-called C-polysaccharide of pneumococci[1].
The plasma concentration of CRP increases as early as 4 hours after induction of the acute phase reaction and within the first two days its concentration increases more than 100-fold. The maximum concentration is reached in 24-48 hours and the half-life of CRP is approximately 24 hours[2].
Physiologically, the plasma concentration is up to 8 mg/l[3]. A rapid and high rise in CRP (typically to values above 60 mg/L) primarily accompanies acute bacterial infections, and less commonly mycotic infections. Viral infections, on the other hand, tend to be characterized by a relatively small rise in CRP (usually below 40 mg/l)[4]. Therefore, determination of plasma CRP concentration helps in deciding whether to initiate antibiotic treatment[1]. Successful antibiotic therapy then results in a rapid decrease in CRP, whereas an increase persists when treatment is unsuccessful.
Determination of CRP can reveal the risk of postoperative infection. On the third day after surgery, its concentration should rapidly decrease to normal. A persistent increase or only a partial decrease, followed by a further increase, indicates the presence of infection or other inflammatory complications.
A slight rise in CRP also accompanies myocardial infarction. In general, that slightly elevated CRP levels (usually around 10 mg/l) are a sign of high cardiovascular risk[5]. Monitoring of CRP concentrations is also useful in monitoring autoimmune diseases[6].
The disadvantage of CRP is its low specificity. Unlike procalcitoninu, it does not inform about the severity of organ involvement, but only about the presence of infection. The two markers are not substitutes for each other but complementary.
References
Related articles
- Procalcitonin
- Blood ▪ Blood plasma ▪ Blood count ▪ Blood sampling for testing ▪ Biochemical analysis of blood ▪ Laboratory acid-base balance testing ▪ Hemoculture ▪ Hemocoagulation ▪ Blood coagulation testing ▪ Bleeding disorders testing ▪ Erythrocyte sedimentation rate
References
- ↑ Jump up to: a b {{{#switch: book |book = Incomplete publication citation. , et al. Klinicka biochemie. Galén, 2006. pp. 71. 978-80-7262-438-6. |collection = Incomplete citation of contribution in proceedings. , et al. Klinicka biochemie. Galén, 2006. pp. 71. {{ #if: 80-7262-324-9 |978-80-7262-438-6} } |article = Incomplete article citation. , et al. 2006, year 2006, pp. 71, |web = Incomplete site citation. , et al. Galén, ©2006. |cd = Incomplete carrier citation. , et al. Galén, ©2006. |db = Incomplete database citation. Galén, ©2006. |corporate_literature = , et al. Klinicka biochemie. Galén, 2006. 978-80-7262-438-6} }, s. 71.
- ↑ {{#switch: book |book = Incomplete publication citation. , et al. Laboratory diagnostics. Galén and Karolinum, 2007. 978-80-7262-438-6. |collection = Incomplete citation of contribution in proceedings. , et al. Laboratory diagnostics. Galén and Karolinum, 2007. {{ #if: 978-80-246-1423-6 |978-80-7262-438-6} } |article = Incomplete article citation. , et al. 2007, year 2007, |web = Incomplete site citation. , et al. Galén and Karolinum, ©2007. |cd = Incomplete carrier citation. , et al. Galén and Karolinum, ©2007. |db = Incomplete database citation. Galén and Karolinum, ©2007. |corporate_literature = , et al. Laboratory diagnostics. Galén and Karolinum, 2007. 978-80-7262-438-6} }
- ↑ {{#switch: web |book = Incomplete publication citation. , et al. Normal Values [online] . Great Medical Dictionary Online, Also available from <http://lekarske.slovniky.cz/normalni-hodnoty>. |collection = Incomplete citation of contribution in proceedings. , et al. Normal Values [online] . Great Medical Dictionary Online, Also available from <http://lekarske.slovniky.cz/normalni-hodnoty>. {{ #if: |978-80-7262-438-6} } |article = Incomplete article citation. , et al. also available from <http://lekarske.slovniky.cz/normalni-hodnoty>. |web = Incomplete site citation. , et al. Great Medical Dictionary Online, [cit. 2020-02-13]. <http://lekarske.slovniky.cz/normalni-hodnoty>. |cd = Incomplete carrier citation. , et al. Great Medical Dictionary Online, [cit. 2020-02-13]. |db = Incomplete database citation. Great Medical Dictionary Online, [cit. 2020-02-13]. <http://lekarske.slovniky.cz/normalni-hodnoty>. |corporate_literature = Incomplete citation of company literature. , et al. Normal Values [online] . Great Medical Dictionary Online, Also available from <http://lekarske.slovniky.cz/normalni-hodnoty>. legislative_document = Incomplete citation of legislative document. Also available from URL <http://lekarske.slovniky.cz/normalni-hodnoty>.
- ↑ {{#switch: book |book = Incomplete publication citation. . Laboratory Dagnostics. Scientia medica, 1993. Memorix; pp. 52. 978-80-7262-438-6. |collection = Incomplete citation of contribution in proceedings. . Laboratory Dagnostics. Scientia medica, 1993. Memorix; pp. 52. {{ #if: 80-85526-12-3 |978-80-7262-438-6} } |article = Incomplete article citation. . 1993, year 1993, pp. 52, |web = Incomplete site citation. . Scientia medica, ©1993. |cd = Incomplete carrier citation. . Scientia medica, ©1993. |db = Incomplete database citation. Scientia medica, ©1993. |corporate_literature = . Laboratory Dagnostics. Scientia medica, 1993. Memorix; 978-80-7262-438-6} }, s. 52.
- ↑ {{#switch: book |book = Incomplete publication citation. , et al. Cardiology. Galén, 1999. pp. 168. 978-80-7262-438-6. |collection = Incomplete citation of contribution in proceedings. , et al. Cardiology. Galén, 1999. pp. 168. {{ #if: 80- 7262-021-5 |978-80-7262-438-6} } |article = Incomplete article citation. , et al. 1999, year 1999, pp. 168, |web = Incomplete site citation. , et al. Galén, ©1999. |cd = Incomplete carrier citation. , et al. Galén, ©1999. |db = Incomplete database citation. Galén, ©1999. |corporate_literature = , et al. Cardiology. Galén, 1999. 978-80-7262-438-6} }, s. 168.
- ↑ {{{#switch: book |book = Incomplete publication citation. . Internal Medicine. Galén a Karolinum, 2006. 1158 s. 978-80-7262-438-6. |collection = Incomplete citation of contribution in proceedings. . Internal Medicine. Galén a Karolinum, 2006. 1158 s. {{ #if: 80-7262-430-X |978-80-7262-438-6} } |article = Incomplete article citation. . 2006, year 2006, |web = Incomplete site citation. . Galén a Karolinum, ©2006. |cd = Incomplete carrier citation. . Galén a Karolinum, ©2006. |db = Incomplete database citation. Galén a Karolinum, ©2006. |corporate_literature = . Internal Medicine. Galén a Karolinum, 2006. 1158 s. 978-80-7262-438-6} }
