Occupational peripheral nerve damage

Toxic damage

• Toxic neuropathhy
• Typical character – symmetric, sensorimotor, distal polyneuropathy
• Sensory fibers are affected first because their bodies are in the dorsal root ganglion (i.e. outside the blood-brain barrier).
• It is distal because the part of the neuron that is furthest from the center of regeneration (i.e. from the cell body) suffers the most
• The longer the axon, the more susceptible it is to damage

Symptoms

• Sensory - Paresthesia or tingling especially at night. Reduction or disappearance of reflexes - distal ones disappear first (e.g. Achilles tendon reflex)
• Motor disorders appear later – typically there is Peroneal paresis (patient can't extend (lift) toes)

Examination

• Electromyography (Sural nerve, Tibial nerve)

Toxicity

• Lead, Mercury
• Organic solvents – carbon disulfide, hexane, trichloroethylene, acrylamide, polychlorinated biphenyl

Dif. dg

Symptoms are nonspecific:

• Mainly – alcoholic polyneuropathy (we will examine GGT (gamma-glutamyl transferase), CDT (carbohydrate-deficient transferrin))
• Diabetic, Paraneoplastic (mainly lung, ovarian, or hematogenous)
• Both in DM and in tumours, polyneuropathy can be the first symptom (must be considered when polyneuropathy occurs)

Therapy

• Termination of toxic exposure, vitamins B1, B6, B12, E, vasoactive substances, nootropics, pain medications – anti-epileptics

Overuse damage

• Tunnel syndromes
• 80% of patients have carpal tunnel syndrome. Cubital tunnel syndrome is the second-most common

Other rare damages:

• Peroneal nerve – compression when passing behind the head of the fibula (e.g. while squatting or kneeling)
• Tibial nerve – pressure in the tarsal tunnel (when passing behind the inner ankle)
• With frequent tiptoeing (plantar flexion) – Ballerinas (damage to the nerve by stretching), Jockeys (tightening in the stirrups), house painters (on stepladders)

Carpal tunnel syndrome

• There will be some expansion of the carpal tunnel – it has two main etiologies
  • Endogenous - hormonal changes (the syndrome will manifest itself bilaterally), inflammation (tendovaginitis), and metabolic changes
  • Exogenous – post-traumatic, from manual work
• The most common groups of activities leading to the syndrome:
  • Heavy physical work: flexor contractions (hammer, heavy loads)
  • Stereotypic repetition of finger flexion and extension (previously in milking cows, musicians, or typing)
  • Fine work with constant pinching of the fingers (watchmakers, fine mechanics)
  • Direct pressure on the wrist (dentists, scissor work, etc.)

• Subjective symptoms:
  • First phase – morning numbness in the fingers
  • Second phase - nocturnal paresthesia
  • Third phase – daytime paresthesia (mainly when working with hands above the head (for example, holding on to a handrail in public transport))
  • Fourth stage – clumsiness of small movements

• Objective signs – sensitivity disorders – we assess them on the 2nd finger (we compare sensation on the belly of the 2nd and 5th finger - the palmar part of the fifth finger is innervated by the ulnar nerve)
• As stated motor defects arise later – mainly abductor pollicis brevis muscle atrophy
• We demonstrate the sign of a candle - hand palm up, thumb sticking up, we push it into the palm,
• the resulting atrophy of this muscle makes such a dimple laterally on the thenar
• sensation on the thenar is normal (the subcutaneous branch originates from the median nerve before entering the tunnel!!!)
• pseudoneuroma of the median nerve is formed - a spindle-like thickening of the nerve - as axoplasm accumulates there due to oppression
• provocation tests – Tinel's sign – tapping the retinaculum with a hammer causes paresthesias
• wrist hyperflexion will do the same
• laboratory objectification - ENG (electroneurography) - the conduction speed of the axon on the forearm and palm will be normal, there is a slowdown in the tunnel

Dif. dg

• syndrom pronator teres (útlak medianu proximálně na předloktí), kořenový syndrom C6, cervikobrachiální syndrom

Léčba

• vyřazení z expozice, polohování dlahou, vazoaktivní látky, NSA, lokálně kortikoidy
• poslední možnost – operace – obvykle se už pracovník nemůže vrátit do práce, neboť pohyb zápěstím je alterován

Jiné syndromy

• paréza n. ulnaris v sulcus nervi ulnaris u kuličů skla

Poškození z vibrací

Iron

Odkazy

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• Nemoc z ozáření
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Použitá literatura

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