Molecular basis of immunoglobulin diversity of primary and secondary antibody response, somatic recombination, isotype skipping.
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Antibodies are an important line of defense against pathogen that invade our bodies. However, their function is reliant on their ability to recognize the antigen and their ability to bind to an antibody facilitates an immune cascade that leads to neutralization of the threat to our body
Molecular basis of immunoglobulin diversity of primary and secondary antibody response[1][edit | edit source]
Antibodies most often known for the role and immune cascade they initiate after being triggered by the presence of antigen. However, a pre immune antibody repertoire is important part of the defense our body builds against pathogens. And the role antibodies are most known for are a which is it's high affinity to an antigen post stimulation result of somatic hypermutation[2]
- Pre immune antibody repertoire refers to the antibodies that are produced by the human body in the absence of stimulation by an antigen.
- This process is driven by somatic recombination
- This produces an wide array of
References[edit | edit source]
- ↑ Alberts, B. (1970) The generation of antibody diversity, Molecular Biology of the Cell. 4th edition. Available at: https://www.ncbi.nlm.nih.gov/books/NBK26860/ (Accessed: 06 April 2025).
- ↑ Hagel, K. (2019) Somatic recombination, ImmunoBites. Available at: https://immunobites.com/2018/11/12/somatic-recombination/ (Accessed: 06 April 2025).
