ANCA
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náhled|vpravo|250px|ANCA positive, cANCA type imunofluorescence, antibodies targeting proteinase e3 (PR3).
náhled|vpravo|250px|ANCA positive, pANCA type imunoflourescence, antibodies targeting myeloperoxase.
ANCA (antineutrophil cytoplasmic antibodies) are autoantibodies targeted against various antigens found in neutrophils (proteinase 3, myeloperoxidase, elastase, cathepsin G, azurocidin, lactoferrin, lysozyme and BPI). Standart in detection of ANCA is direct immunofluorescence on ethanol-fixed human neutrophils.
Due to the different distribution of the above proteins, three types of positivity are described:
- cANCA: cytoplasmatic immunofluorescence;
- pANCA: perinuclear immunofluorescence;
- xANCA or aANCA: atypical immunofluorescence.
ANCAs are typically detectable in vasculitis. cANCA are characteristic for Wegener's granulomatosis, pANCA for polyarteritis. ANCA can be detected in a number of other diseases.
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Related articles[edit | edit source]
Literature[edit | edit source]
- HRDÁ, P. – ŠTERZL, I.. Vyšetření autoprotilátek – současné možnosti. Interní medicína pro praxi [online]. 2003, vol. 5, no. 8, p. 410-413, Available from <http://www.internimedicina.cz/pdfs/int/2003/08/07.pdf>. ISSN 1803-5256.
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↵ANCA (antineutrophil cytoplasmic antibodies) are autoantibodies targeted against various antigens found in neutrophils (proteinase 3, myeloperoxidase, elastase, cathepsin G, azurocidin, lactoferrin, lysozyme and BPI). Standart in detection of ANCA is
direct immunofluorescence
on ethanol-fixed human neutrophils.↵
↵
↵Due to the different distribution of the above proteins, three types of positivity are described:
cANCA: cytoplasmatic immunofluorescence;
pANCA: perinuclear immunofluorescence;
xANCA or aANCA: atypical immunofluorescence.
ANCAs are typically detectable in vasculitis. cANCA are characteristic for Wegener's granulomatosis
, pANCA for polyarteritis. ANCA can be detected in a number of other diseases.
Links
Related articles
Literature
- HRDÁ, P. – ŠTERZL, I.. Vyšetření autoprotilátek – současné možnosti. Interní medicína pro praxi [online]. 2003, vol. 5, no. 8, p. 410-413, Available from <http://www.internimedicina.cz/pdfs/int/2003/08/07.pdf>. ISSN 1803-5256.
