Lysosome-related organelles

An example of an LRO is a platelet delta granule

• LROs stands for lysosome-related organelles, which are lysosome-like organelles that have membrane parameters of lysosomes and some of their enzymes, but only residual or zero degradation activity (unlike lysosomes).

• These organelles include:
  • Azurophilic granules of eosinophilic and neutrophilic granulocytes, the disorders of which lead, among other things, to intestinal diseases.
  • Melanosomes of melanocytes whose deficiency leads to a specific type of albinism.
  • Delta granules of platelets, the disorder of which leads to increased bleeding.
  • Lytic granule of NK cells and Tc lymphocytes, the disorder of which leads to immunodeficiency.
  • Secondary granules of pneumocytes II, whose disorder leads to pulmonary fibrosis.
  • Osteoclast lysosomes

• Syndromes with LRO include Chediak-Higashi syndrome and Hermansky-Pudlak syndrome.