View source for Electrocardiography

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[[File:Electrocardiography Basics.webm|thumb]]
Electrocardiography (ECG/EKG) is the basic diagnostic method in cardiology. It monitors the heart's electrical activity (as an electrocardiogram) as measured from the surface of the body and allows its evaluation. ECG examinations are mostly non-invasive using electrodes placed on the skin. However it is also possible to measure the ECG from the esophagus wall or right on the heart's surface. 

Since the electrical activity of the heart is very important for its mechanical activity, the ECG has an important diagnostic role in a number of heart diseases. In addition, we can detect disturbances arising from extra-cardiac causes (eg. thyroid dysfunction, ionic dysbalance). However, the ECG examination on it's own is not enough to produce a complete diagnosis.

== Indications ==
ECG is indicated if there is suspicion onf
* '''heat disease''': [[heart attack]], [[Arrhytmia|arrhythmias]], [[conduction disturbance]]s, [[myocardial ischemia]];
* '''metabolic disease''': [[Calcium|hypocalcemia or hypercalcemia]], [[Potassium|hypokalemia or hyperkalemia]];
* '''endocrine disease''': diseases of the [[thyroid gland]] ([[hypothyroidism]] and [[hyperthyroidism]]).

== Principle ==
[[File:ECG Principle fast.gif |thumb|right| 150 px ]]
The myocardial potential spreads from the heart to the surface of the body as body tissues and fluids are good conductors of electricity.

'''W. Einthoven (1860-1927)'''

The capture of these potentials was introduced by the Dutch physiologist Willem Einthoven in the early 20th century. He used the three standard bipolar limb leads (I, II, III), still in use today, forming the so-called Einthoven triangle, in which the heart lies at the imaginary centroid. The principle of these leads is the connection of two active electrodes whose polarity is predetermined. The leads then record the potential difference between the electrodes and indicate the resulting amplitude. ''The vector sum of all three amplitudes of these limbs is equal to zero (Einthoven's law).''

Today ECG measurement is improved by adding additional leads. They are called unipolar leads as the potential is always measured relative to a constant potential given by the average potential of the the RA, LA and LL potentials i.e., (RA + LA + LL)/3  called the '''Wilson potential)''', which is conventionally set as a reference zero potential. Thus, we obtain additional 'Goldberger augmented' limb leads (aVR, aVL, aVF) and the thoracic (V1-V6) leads. Therefore the most common ECG electrocardiagram has currently 12-leads. Under special circumstances, other leads may be used.

[[<iframe width="560" height="315" src="https://www.youtube.com/embed/xIZQRjkwV9Q" frameborder="0" allow="accelerometer; autoplay; encrypted-media; gyroscope; picture-in-picture" allowfullscreen></iframe>]]

== [[ECG Leads]] ==
{{Edit article|ECG_Leads}}{{:ECG Leads}}

== ECG curve ==
The spread of myocardial depolarization is different, depending on which lead is sensing the potential, that is, in which direction and in which plane it is located relative to the heart. The path of propagation of the potential from the heart has a typical character and produces typical waves, oscillations and lines that correspond to different phases of the cardiac cycle.
[[File:EKG Complex pt.png|thumb|ECG curve segment]]
*'''P wave''' - depolarization and contraction of the atrium,
*'''PQ interval''' - depolarisation spreading from the atria to the ventricles,
*'''QRS complex''' - ventricular depolarization and contraction,
**Q = negative wave preceeding the R wave,
**R = any positive wave of the QRS complex,
**S = negative wave following the R wave,
*'''T wave''' - repolarization of the ventricles,
*'''U wave''' - not always seen, its origin is not completely clear.
[[File:Basic representation of cardiac conduction.gif|thumb|Simple representation of conduction through cardiac electrical pathways and myocardium. Red -> depolarisation. Blue -> depolarised cells. Yellow -> repolarised cells. Normal diagram -> resting potential. Represents SA, Atrium, AV (delay), BBB & Purkinje fibres.]]
The myocardial action potential normally arises from spontaneous depolarization in the sinoatrial node (SA), from where it spreads to the atrial muscles. The instantaneous final vector has a relatively small amplitude due to the thin wall of the atrium, and is pointing left down. In the ECG record it appears to be the '''P wave'''. Slow conduction in the atrioventricular node (AV) slows down the propagation of depolarization from the atria to the ventricles to separate the atrial systole from the ventricular systole. In the ECG graph it is visible as an isoelectric line ('''PR'''). 

This is followed by depolarization of the ventricles, forming the '''QRS complex''' in the ECG record. The impulse progresses through the ''Hiss bundle'' and ''Tawar's arm'' to the muscles of the interventral septum, where depolarization spreads from left to right, thus the instantaneous vector directs right down. In the ECG is either a negative Q, or a positive R wave, depending on the lead. In the next step the excitation spreads to the heart apex, the instantaneous vector points to the left down direction, forming the central part of the QRS complex, in most leads it is the '''R wave'''. From there, depolarization spreads through the ''Purkyne fibers'' to the working myocardium of the two ventricles, from the endocard to the epicard. In the instantaneous vector the left ventricle's thick muscularity plays a role, so the vector points to the left. And in the end it points in the up and left direction when depolarizing the basal portion of the left ventricle, whilst completing the ventricular QRS complex.

After the depolarization is complete, the electrical heart activity is zero for a while, the muscular fibers are in the plateau phase, when no electrical currents flow through the myocardium. In the ECG record will be shown as an ''isoelectric line - '''ST''' segment''. After this moment, ventricular repolarization begins, which goes backwards from the epicardium to the endocardium. Thus, a '''wave T''' is formed. Sometimes a '''U wave''' can be recorded on the ECG record, the origin of which is not known precisely, it is probably the manifestation of papillary muscles repolarization.
[[File:ECG Paper.svg|thumb|255x255px]]

== Electrocardiogram ==
The ECG is captured on millimeter paper. To correctly subtract the values, we must have:
* '''calibration pulse 1mV''' (corresponding to amplitude), usually = '''10 mm''',
* '''paper feed rate''' of either '''50 mm / s''' (1 mm → 0.02 s) or '''25 mm/s''' (1 mm → 0.04 s)[[File:12leadECG.jpg|thumb|409x409px|Eletrocardiogram]]
<u>The ECG record evaluation consists of ten points:</u>
# cardiac action
# heart rhythm
# heart rate
# wave P
# PQ interval
# QRS complex
# ST segment
# wave T
# QT interval
# axis of the heart
[[File:Myocardial infarction ECG.svg|thumb|426x426px|Myocardial infarction]]
Evaluation of the electrocardiagram allows us to detect arrhythmias, as a sign of malfunctions of electric impluse creation or propagation. It also plays an important role in the detection of ischemic changes, localization and stage of '''myocardial infarction'''. Changes in the ECG are found either in all leads, or in just one, or the group of leads that are related to the particularl paart of the anatomy of the heart which is affected. For example the locus of myocardial infarction (IM) can be determined by the knowledge of its vascular supply and the projection of the heart sections on the surface of the body in a relation to the direction of recording of individual leads.

{| class="wikitable"
!Abnormalities localisation (IM)
!Leads
|-
|lateral
|I, aVL, V5, V6
|-
|diaphragmatic (down)
|II, III, aVF
|-
|anteroseptal
|V1–V3
|-
|whole anterior myocard
|V1–V6
|-
|antral
|aVR
|}

== [[Electrocardiogram|Normal ECG]] ==
{{Edit article|Electrocardiogram}}{{:Electrocardiogram}}
<noinclude>
== Links ==
=== Related Articles ===
* [[Heart Autorhythmicity]]
* [[ECG Abnormalities]]
=== References ===
<references />
=== Bibliography ===
* {{Cite
| type = book
| surname1 = Kasper
| name1 = Dennis L
| surname2 = Fauci
| name2 = Anthony S
| surname3 = Longo
| name3 = Dan L
| others = yes
| title = Harrison's principles of Internal Medicine
| edition = 16th
| location = New York
| publisher = McGraw-Hill Companies, Inc
| year = 2005
| range = 2607
| pages = 1311-1319
| isbn = 0-07-139140-1
}}

</noinclude>

[[Category:Physiology]]
[[Category:Cardiology]]
[[Category:Internal Medicine]]