View source for Thick skin (histological preparation)

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[[File:Thick Skin Type 2.jpg |right|preview| 150px | Thick-type skin, stained with H&E]]
[[File:Thick type skin.jpg|right|preview| 150px | Thick-type skin - detail, stained with H&E]]

== Layers ==
=== Epidermis ===
The [[Epidermis]] (skin) consists of a '''stratified squamous'''' [[epithelium]] with a '''keratinization''. It regularly runs into the dermis layer and thus creates "epidermal ridges". On the cross-section, we distinguish five layers (layer = ''stratum''):
* str. basale: cubic to cylindrical basophilic elements in a single layer that sit on the lamina basalis. The only intercellular junctions are '''desmosomes''''
* pp. spinosum: cubic polygonal elements with cytoplasmic protrusions. We find tonofibrils in them,
* str. granulosum: basophilic layer with keratohyaline granules (stains intensely dark purple),
* pp. lucidum: a thin translucent layer, the cells no longer have [[nucleus|nuclei]] or [[organelles]], they are filled mainly with keratin filaments,
* pp. corneum: anucleate cornified elements.

Pg. basale and str. spinosum are referred to by the common name '''str. germinativum'' (germ layer).

=== Dermis ===
The dermis (Slovak suede, Czech skára) develops from [[mesenchyme|mesenchyme]] and consists of connective tissue that strengthens the epidermis. In some places, it runs into the epidermis and thus creates "dermal papillae". It consists of two layers:
* pp. reticulare: dense tissue,
* pp. papillare: thin ligament.

=== Hypodermis ===
The hypodermis (subcutaneous tissue) consists of thin tissue, [[adipocytes]], [[sweat glands|sweat glands]] (eccrine – simple coiled tubular glands opening onto the surface of the skin, basally surrounded by myoepithelial cells).

== Links ==
=== Related Articles ===
* [[Physiological activity of the skin]]
* [[Histopathological changes in the skin]]

=== References ===
* {{Citation
|type = web
|corporation =
|surname1 = MUDr. Eis
|name1 = Wenceslas
|surname2 = MUDr. Jelinek
|name2 = Stephen
|surname3 = MUDr. Starling
|name3 = Martin
|collective = no
|name = Histopathological atlas
|year = 2006
|revision_date =
|cited = 2010-04-15
|url = http://histologie.lf3.cuni.cz/histologie/atlas/index.htm
}}
* {{Citation
|type = book
|corporation =
|surname1 = Junquiera
|name1 = L. Carlos
|surname2 = Carneiro
|name2 = Jose
|lastname3 = Kelley
|name3 = Robert O.
|collective =
|title = Basics of histology
|issue = 1
|place = Jinocany
|publisher = H & H 1997
|year = 1997
|range= 502
|edition =
|bundle =
|isbn = 80-85787-37-7
|sides =
|url=
}}
</noinclude>

[[Category:Histology]]
[[Category:Dermatovenerology]]