Heparan sulfate: Difference between revisions
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'''Heparan sulfate''' is a linear [[ | '''Heparan sulfate''' is a linear [[Polysaccharides|polysaccharide]]. It is most often found in the human body in the form of [[Proteoglykany|proteoglycan]], when its molecules are bound to an axis protein . | ||
[[File:Struktura heparinu.png|thumb|Structure of heparin]] | [[File:Struktura heparinu.png|thumb|Structure of heparin]] | ||
=== The role of heparan sulfate in the glomerular membrane === | === The role of heparan sulfate in the glomerular membrane === | ||
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__TOC__ | __TOC__ | ||
=== Anticoagulant effect of heparan sulfate === | === Anticoagulant effect of heparan sulfate === | ||
Heparan sulfate is found on [[Endotelové buňky|endothelial cells]]. It binds to '''[[ | Heparan sulfate is found on [[Endotelové buňky|endothelial cells]]. It binds to '''[[antithrombin III]]''' and increases its inhibitory capacity. | ||
Thanks to this, the activity of [[ | Thanks to this, the activity of [[thrombin]] and other [[Koagulační faktory|coagulation factors]] is reduced. | ||
=== Heparan sulfate and metabolic syndrome === | === Heparan sulfate and metabolic syndrome === | ||
Increased accumulation of heparan sulfate and other [[Proteoglykany|proteoglycans]] is the essence of some [[ | Increased accumulation of heparan sulfate and other [[Proteoglykany|proteoglycans]] is the essence of some [[Mucopolysaccharides|mucopolysaccharidoses]]. These are diseases in which proteoglycans accumulate in tissues. The essence is usually a defect in an enzyme that is responsible for breaking down the given proteoglycan. | ||
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Revision as of 15:32, 9 December 2022
Heparan sulfate is a linear polysaccharide. It is most often found in the human body in the form of proteoglycan, when its molecules are bound to an axis protein .
The role of heparan sulfate in the glomerular membrane
In the filtration membrane of the kidney glomerulus, heparan sulfate acts as an ion filter . When the lamina basalis of the podocyte and the lamina basalis of the capillary fuse, a three-layered membrane is formed Consists of
- lamina rara subendothelialis,
- lamina densa,
- lamina rara subepithelialis.
Lamina densa serves as a mechanical filter. Laminae rarae are rich in heparan sulfate, which has the already mentioned ion filtering function. Due to the fact that heparan sulfate carries a negative charge, positively charged particles pass through this part of the membrane most easily, neutral ones pass through more difficult, and negative ions pass through the most difficult.
Anticoagulant effect of heparan sulfate
Heparan sulfate is found on endothelial cells. It binds to antithrombin III and increases its inhibitory capacity.
Thanks to this, the activity of thrombin and other coagulation factors is reduced.
Heparan sulfate and metabolic syndrome
Increased accumulation of heparan sulfate and other proteoglycans is the essence of some mucopolysaccharidoses. These are diseases in which proteoglycans accumulate in tissues. The essence is usually a defect in an enzyme that is responsible for breaking down the given proteoglycan.
