Gardner's syndrome: Difference between revisions
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[[File:22013-gardner-syndrome.jpg|thumb|Gardner's syndrome symptoms]] | |||
'''Colon polyposis''' with concomitant finding [[Osteomalacia|of osteomas]] and fibromatosis. Caused by a [[mutation in the APC gene]] (5q21; OMIM: 611731 ). | '''Colon polyposis''' with concomitant finding [[Osteomalacia|of osteomas]] and fibromatosis. Caused by a [[mutation in the APC gene]] (5q21; OMIM: 611731 ). | ||
It is characterized by the presence of a large number of adenomas in the colonic mucosa (over 100), the size of which varies from small dimensions to 3 cm. They appear around the age of 25 and over the next 10-15 years, almost 100% of them develop [[Cancer Families|cancer]], sometimes multiple. Similar to '''adenomatous familial polyposis''' , in which, however, osteomas and fibromatoses do not form. | It is characterized by the presence of a large number of adenomas in the colonic mucosa (over 100), the size of which varies from small dimensions to 3 cm. They appear around the age of 25 and over the next 10-15 years, almost 100% of them develop [[Cancer Families|cancer]], sometimes multiple. Similar to '''adenomatous familial polyposis''', in which, however, osteomas and fibromatoses do not form. | ||
== Links == | == Links == | ||
Revision as of 17:05, 15 February 2022
Colon polyposis with concomitant finding of osteomas and fibromatosis. Caused by a mutation in the APC gene (5q21; OMIM: 611731 ).
It is characterized by the presence of a large number of adenomas in the colonic mucosa (over 100), the size of which varies from small dimensions to 3 cm. They appear around the age of 25 and over the next 10-15 years, almost 100% of them develop cancer, sometimes multiple. Similar to adenomatous familial polyposis, in which, however, osteomas and fibromatoses do not form.
