Acetyl-CoA: Difference between revisions
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[[File:Acetyl-CoA.svg|thumb|Acetyl-CoA]] | [[File:Acetyl-CoA.svg|thumb|Acetyl-CoA]] | ||
'''Acetyl coenzyme A''' (Ac-CoA) is a central molecule especially in the metabolism of [[ | '''Acetyl coenzyme A''' (Ac-CoA) is a central molecule especially in the metabolism of [[carbohydrates]], lipids, proteins and other substances. It is activated acetic acid to which '''[[coenzyme A]]''' is attached via a sulfur atom. In its excess, when the capacity of the citrate cycle is exceeded, it is a substrate for [[Formation of ketone bodies|ketogenesis]]. | ||
__NOTOC__ | __NOTOC__ | ||
Acetyl coenzyme A is produced during the '''decarbocylation of pyruvate''' by the irreversible PDH reaction, a large amount is produced during the '''[[ | Acetyl coenzyme A is produced during the '''decarbocylation of pyruvate''' by the irreversible PDH reaction, a large amount is produced during the '''[[Beta-oxidation|β-oxidation]]''' of fatty acids, it is also produced during the '''degradation of some amino acids'''. It can be formed by the direct enzymatic connection of acetyl and coenzyme A with the consumption of [[Adenosine triphosphate|ATP]]. | ||
It is a [[ | It is a [[Macroergic compounds|macrogenic compund]], the macroergic bond energy is 32 kJ/mol.<ref name="duska">{{Citace | ||
| typ = kniha | | typ = kniha | ||
| příjmení1 = Duška | | příjmení1 = Duška | ||
Revision as of 15:38, 18 December 2022
Acetyl coenzyme A (Ac-CoA) is a central molecule especially in the metabolism of carbohydrates, lipids, proteins and other substances. It is activated acetic acid to which coenzyme A is attached via a sulfur atom. In its excess, when the capacity of the citrate cycle is exceeded, it is a substrate for ketogenesis.
Acetyl coenzyme A is produced during the decarbocylation of pyruvate by the irreversible PDH reaction, a large amount is produced during the β-oxidation of fatty acids, it is also produced during the degradation of some amino acids. It can be formed by the direct enzymatic connection of acetyl and coenzyme A with the consumption of ATP.
It is a macrogenic compund, the macroergic bond energy is 32 kJ/mol.[1]
Links
Related articles
References
- Wikipedia editors. Acetyl coenzyme A [online]. Wikipedia: The Open Encyclopedia, Last revised 5/6/2011, [cit. 2011-08-01]. < https://cs.wikipedia.org/wiki/Acetylcoenzym_A >.
Reference
- DUŠKA, František and Jan TRNKA. Biochemistry in context Part I - basics of energy metabolism. 1st edition. Prague: Karolinum, 2006. p. 25. ISBN 80-246-1116-3 .
