Glycylcyclines: Difference between revisions
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(Original from wikiscripta : Glycylcykliny) |
(Original from wikiscripta : Glycylcykliny) |
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Glycylcyclines represent a new group of [[antibiotics|antibiotics]] that is derived from the [[tetracycline|tetracycline]] antibiotic [[tetracyclines#Representatives|minocycline]]. The main representative is '''tigecycline''''. Tigecycline is a broad-spectrum ATB (effective against Gram-negative, Gram-positive and anaerobic microbes, but not effective against [[Pseudomonads|pseudomonads]] and [[proteus|proteums]]). Tigecycline is chemically a ``9-t-butylglycylamido derivative of minocycline''. | |||
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=== | === Indication === | ||
They are indicated for complicated [[skin]] and soft tissue infections as well as intra-abdominal infections. | |||
=== | === Mechanism of action === | ||
Their mechanism of action is: inhibition of [[proteosynthesis|proteosynthesis]], (blocking of [[translation]] of [[protein]] in bacteria by binding to the '''ribosomal subunit 30S'''', blocks the entry of aminoacyl-tRNA molecules into the A site of the ribosome ). | |||
=== | === Antimicrobial spectrum === | ||
It is a '''broad-spectrum antibiotic'''' that acts on many clinically important [[bacteria]]. Both gram-positive, gram-negative, anaerobic and atypical, including some multi-resistant, [[penicillin]] resistant ''[[Streptococcus pneumoniae]]'', ''[[Klebsiella pneumoniae]]'' and ''[[Escherichia coli ]]'', ''[[Staphylococcus aureus]]'', from gram-negative bacteria shows a lower sensitivity to ''[[Pseudomonas aeruginosa]]'', ''Proteus mirabilis'', ''Burkholderia cepacia'' and '' Stenotrophomonas malthophilia''. | |||
=== | === Side effects === | ||
Side effects are: | |||
* [[ | * [[nausea]], | ||
* [[vomitus| | * [[vomitus|vomiting]], | ||
* [[ | * [[diarrhea]]. | ||
<noinclude> | |||
== Links == | |||
== | |||
=== | === Related articles === | ||
* [[ | * [[Antibiotic to treat staphylococcal infection]] | ||
* [[ | * [[Tetracycline antibiotics]] | ||
* [[ | * [[Antibiotic resistance]] | ||
=== | === References === | ||
* {{ | * {{Cite | ||
| | | type = článek | ||
| | | surname1 = Vojtová | ||
| | | name1 = Vladimíra | ||
| | | surname2 = Urbánek | ||
| | | name2 = Karel | ||
| | | article = Glycylcyclins - A new group of antibiotics | ||
| | | journal = Klin Farmakol Farm | ||
| | | year = -2008 | ||
| | | the_year = 3 | ||
| | | number = 22 | ||
| | | pages = 113–115 | ||
| issn = 1803-5353 | | issn = 1803-5353 | ||
| url = http://www.solen.cz/pdfs/far/2008/03/06.pdf | | url = http://www.solen.cz/pdfs/far/2008/03/06.pdf | ||
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</noinclude> | </noinclude> | ||
{{Navbox - ATB}} | {{Navbox - ATB}} | ||
[[ | [[Category:Pharmacology]] | ||
[[ | [[Category:Infectious Medicine]] | ||
[[ | [[Category:Microbiology]] | ||
Revision as of 20:28, 26 January 2023
Glycylcyclines represent a new group of antibiotics that is derived from the tetracycline antibiotic minocycline. The main representative is tigecycline'. Tigecycline is a broad-spectrum ATB (effective against Gram-negative, Gram-positive and anaerobic microbes, but not effective against pseudomonads and proteums). Tigecycline is chemically a ``9-t-butylglycylamido derivative of minocycline.
Indication
They are indicated for complicated skin and soft tissue infections as well as intra-abdominal infections.
Mechanism of action
Their mechanism of action is: inhibition of proteosynthesis, (blocking of translation of protein in bacteria by binding to the ribosomal subunit 30S', blocks the entry of aminoacyl-tRNA molecules into the A site of the ribosome ).
Antimicrobial spectrum
It is a broad-spectrum antibiotic' that acts on many clinically important bacteria. Both gram-positive, gram-negative, anaerobic and atypical, including some multi-resistant, penicillin resistant Streptococcus pneumoniae, Klebsiella pneumoniae and Escherichia coli , Staphylococcus aureus, from gram-negative bacteria shows a lower sensitivity to Pseudomonas aeruginosa, Proteus mirabilis, Burkholderia cepacia and Stenotrophomonas malthophilia.
Side effects
Side effects are:
