Glycylcyclines: Difference between revisions
| Line 36: | Line 36: | ||
| url = http://www.solen.cz/pdfs/far/2008/03/06.pdf | | url = http://www.solen.cz/pdfs/far/2008/03/06.pdf | ||
| year = -2008 | | year = -2008 | ||
| | | volume = 3 | ||
| | | edition = 22 | ||
| pages = 113–115 | | pages = 113–115 | ||
| issn = 1803-5353 | | issn = 1803-5353 | ||
Revision as of 20:33, 26 January 2023
Glycylcyclines represent a new group of antibiotics that is derived from the tetracycline antibiotic minocycline. The main representative is tigecycline'. Tigecycline is a broad-spectrum ATB (effective against Gram-negative, Gram-positive and anaerobic microbes, but not effective against pseudomonads and proteums). Tigecycline is chemically a ``9-t-butylglycylamido derivative of minocycline.
Indication
They are indicated for complicated skin and soft tissue infections as well as intra-abdominal infections.
Mechanism of action
Their mechanism of action is: inhibition of proteosynthesis, (blocking of translation of protein in bacteria by binding to the ribosomal subunit 30S', blocks the entry of aminoacyl-tRNA molecules into the A site of the ribosome ).
Antimicrobial spectrum
It is a broad-spectrum antibiotic' that acts on many clinically important bacteria. Both gram-positive, gram-negative, anaerobic and atypical, including some multi-resistant, penicillin resistant Streptococcus pneumoniae, Klebsiella pneumoniae and Escherichia coli , Staphylococcus aureus, from gram-negative bacteria shows a lower sensitivity to Pseudomonas aeruginosa, Proteus mirabilis, Burkholderia cepacia and Stenotrophomonas malthophilia.
Side effects
Side effects are:
