Genetics in data


Období objevu	Osobnost(i)	Objev
1865	Johan Gregor Mendel	Laws of inheritance (Mendel's laws of inheritance)
1869	Paul Langerhans	He discovered and described the islets of Langerhans in the pancreas (Diabetes mellitus type I a II)
1869	Friedrich Miescher	He isolated DNA for the first time; isolated it in small quantities from white blood cells; was not analyzed further
1879	Walther Flemming	Chromosomes in mitosis (Chromosome, Mitosis)
1892	Dmitri Ivanowski (Дми́трий Ивано́вский)	The term virus (Virus)
1908	Godfrey Harold Hardy a Wilhelm Weinberg	Basic law of population genetics (Hardy-Weinberg equilibrium)
1909	Karl Landsteiner	Blood group system AB0 – classification of people into blood groups A, B, AB, 0; 1930 Nobel Prize
1909	Thomas Hunt Morgan	Linear arrangement of genes on chromosomes, linkage of genes, phase coupling and repulsion; 1933 Nobel Prize (Gene linkage)
1910	Albert Kossel	Cytology - research on proteins and nucleic acids; 1910 Nobel Prize
1911	Peyton Rous	Discovery of a virus with oncogenic potential - domestic chicken sarcomas; 1966 Nobel Prize
1920	Frederick Banting a John J. R. Macleod	Isolation of an active substance from the pancreas for the treatment of diabetes; 1923 Nobel Prize (Multifactorial inheritance, Autoimmune disease)
od 1930	George D. Snell	Discovery of genetic factors that determine the possibility of tissue transplantation, the histocompatibility complex (H-2) of the mouse; 1980 Nobel Prize (Major histocompatibility complex, Transplant laws)
od 1931	William Bateson, Reginald Crundall Punnett	Linkage of genes, crossing-over, recombination; (Gene linkage)
1937-45	George Wells Beadle, Edward Lawrie Tatum	Biochemical and genetic studies on the microorganism Neurospora - determining the ability of genes to regulate certain chemical reactions; 1958 Nobel Prize' (Cell Signaling)
1944	Oswald Avery, Colin MacLeod, Maclyn McCarty	Basic genetic information is stored in DNA
1940-50	Barbara McClintock	The genetic map of maize, the role of centromeres and telomeres and the subsequent discovery of genetic transposition - mobile DNA sequences (transpososomes); 1983 Nobel Prize (Transposomes, Centromere, Telomeres)
1940-60	Peter Brian Medawar, Frank (Macfarlane) Burnet	Transplantation – discovery of acquired immunological tolerance; 1960 Nobel Prize (Transplant laws, Immunological tolerance)
1950 a 1970-80	Edward B. Lewis; Christiane Nusslein-Volhard a Eric F. Wieschaus	Developmental genetics; first Drosophila melanogaster - discovery of the principle of co-linearity (localization of sets of genes on chromosomes is related to the arrangement of body segments). Furthermore, this principle is confirmed for all multicellular animals; 1995 Nobel Prize' (Embryonic Development, Drosophila melanogaster)
1950-61	Francois Jacob, André Lwoff, Jacques Monod	Control and regulation of metabolic pathway enzyme expression by feedback with the DNA sequence (for example, ``E. coli/lactose); 1965 Nobel Prize' (Single-cell models, Prokaryotes)
1950-59	Stanley Cohen, Rita Levi-Montalcini	Isolation of nerve growth factor (NGF), which led to the discovery of epidermal growth factor; 1986 Nobel Prize' (Cell Signaling, (Proto)oncogenes)
1953	James D. Watson, Francis H. C. Crick, Maurice H. Frederics	Determining the structure of DNA; 1962 Nobel Prize
1956	Joe Hin Tjio a Albert Levan	Determining the exact number of chromosomes in human somatic cells (Human karyotype)
1956	Robert W. Holley, Har. G. Khorana, Marshall W. Nirenberg	Role of RNA in protein synthesis, genetic code and its role in protein biosynthesis; 1968 Nobel Prize' (mRNA, Translation)
1957	Arthur Kornberg	While studying the bacterium Escherichia coli, he discovered DNA polymerase; Severo Ochoa and Arthur Kornberg for the discovery of the mechanism of RNA and DNA biosynthesis ' 1959 Nobel Prize
1958	Tuneko Okazaki, Reiji Okazaki	Semiconservative replication process, Okazaki fragments
1958-69	Earl W. Sutherland, Jr.	Isolation of the hitherto unknown cyclic adenosine monophosphate (cAMP), clarification of its role in the metabolism of some hormones; 1971 Nobel Prize' (Cell Signaling)
1959	Jérôme JL Marie Lejeune	Chromosomal basis of Down syndrome - trisomy of chromosome 21 (Down syndrome)
1960-65	Baruj Benacerraf, Jean Dausset	Discovery of MHC and characterization of the genes of the major histocompatibility complex (MHC) of humans and subsequently other vertebrates; 1980 Nobel Prize' (HLA)
od 1960	Alfred Goodman Gilman, Martin Rodbell	Discovery of G-proteins and elucidation of their role in cell signaling; 1994 Nobel Prize' (Cell Signaling)
od 1961	Leonard Hayflick a P. Moorhead	They described a limitation in the number of cell cycles in ``in vitro cultured fibroblasts - the so-called replicative aging (senescence) (Replicative senescence)
1962	Werner Aber, Daniel Nathans, Hamilton O. Smith	Discovery of restriction endonucleases; 1978 Nobel Prize' (Restriction fragment length polymorphism)
1970	David Baltimore, Renato Dulbecco, Howard M. Temin	Oncovirology – interaction of retroviruses with the genetic material of the cell, reverse transcription; 1975 Nobel Prize' (Viral carcinogenesis)
1970-71	Leland Harrison Hartwell, Richard Timothy Hunt, Paul Maxime Nurse	During the study of the cell cycle of yeast (Saccharomyces cerevisiae), genes regulating the cell cycle were discovered; discovery of homologous genes in humans (cyclins and cyclin-dependent protein kinases) (Cell cycle, (Proto)oncogenes)
1970-80	Susumu Tonegawa	Analysis of DNA of the B cells (experiments on mice), discovery of the genetic principle of antibody diversity; 1987 Nobel Prize' (Gene Control of Antibody Formation)
1970-80	John M. Bishop, Harold E. Varmus	Study of the relationship of retroviruses to the development of malignant tumors, discovery of the first human oncogene "c-src"; 1989 Nobel Prize' (Oncoviruses, (Proto)oncogenes)
1975	Edwin Mellor Southern	Vyvinul hybridizační metodu DNA v gelové elektoforéze pro identifikaci specifické sekvence DNA (DNA hybridizace, Southern blot)
1975	John Foxton Ross Kerr	Poprvé popsal apoptózu – geneticky programovanou smrt buněk; Nobelova cena 2002 – Sydney Brenner, H. Robert Horvitz, John E. Sulston- byla udělena za objevy genetické regulace vývoje orgánů a apoptózy (Embryonální vývoj, Stárnutí organismu)
1975-77	Frederick Sanger, Walter Gilbert, Paul Berg	Vyvinuli techniky sekvenování DNA; 1980 Nobelova cena (DNA; Sekvenování); Frederick Sanger získal již jednu Nobelovu cenu v roce 1958 za stanovení polypeptidového řetězce inzulinu (Genetika "civilizačních" onemocnění)
1976	Harald zur Hausen	Objev papiloma viru, který je příčinou vzniku karcinomu děložního čípku; Nobelova cena 2008 (Virová karcinogeneze)
1977	Richard John Roberts, Phillip Allen Sharp	Nezávisle objevili členění genů eukaryotních buněk na úseky (introny a exony) a vystřižení intronů z mRNA (gene-splicing); 1993 Nobelova cena (Struktura genu, Posttranskripční úpravy)
1982	Stanley B. Prusiner	Formuloval teorii o novém původci infekčních onemocnění nervového systému; objev prionů; 1997 Nobelova cena (Priony)
1983	Francoise Barréová-Sinoussiová, Luc Montagnier	Objev viru HIV (Human Immunodeficiency Virus); Nobelova cena 2008 – (Imunodeficience, AIDS)
1984	Elizabeth Blackburnová, Carol Whidney Greiderová, Jack William Szostak	Objev telomer (ochrany konců lineárních chromosomů) a enzymu telomerázy; Nobelova cena 2009 – (Telomery a telomerasa)
1985	Kary Banks Mullis s kolegy	Vyvinul metodu PCR (Polymerase Chain Reaction) umožňující namnožit i z jediné molekuly DNA vybraný úsek dědičné informace; Nobelova cena 1993 – (DNA, Polymerasová řetězová reakce)
1988-2001	Projekt HUGO	Sekvenování lidského genomu; Mezinárodní konsorcium Human Genome Project a americká soukromá společnost Celera Genomics – "hrubé" přečtení genomu (DNA, Mapování genomu)
1989	Mario Renato Capecchi, Martin Evans, Oliver Smithies	Studium embryonálního vývoje – myší embryonální kmenové buňky, knockout myši; Nobelova cena 2007 – (Kmenové buňky, Knockout myš, Mus musculus)
1990	Stephen F. Altshul, Gish W., David J. Lipmann, Miller W., Eugene Wilson Meyers	Vytvořili algoritmus BLAST (Basic Local Alignment Search Tool) pro vypočítání podobnosti sekvencí a následné dohledávání genů a proteinů na základě vzájemné homologie (in silico – počítačové modely)
1990	William French Anderson	První provedl genovou terapii u 4letého dítěte trpícího imunodeficiencií (SCID – Severe Combined Immunodeficiency); výsledek léčby byl částečný. 2001 Alan Fisher genovou terapií SCID vyléčil (Imunodeficience)
1996	ovce Dolly	První naklonování savce z jediné tělní buňky (Kmenové buňky)
1998	Andrew Z. Fire, Craig C. Mello	Objev RNA interference – systému kontroly aktivity některých (specifických) genů; Nobelova cena 2006 (Transkripce, RNA interference)
2012	Jennifer A. Doudna, E. Charpentier	Cílená editace genomu pomocí CRISPR/Cas9; Nobelova cena 2020