Benign salivary gland tumors

• Benign salivary gland tumors are highly variable.
• Occurrence is independent of gender.
• They usually grow slowly and painlessly.
• Epithelia are more common than mesenchyme.
• Therapy is surgical.
• Pleomorphic adenoma (mixed tumor, myxochondroepithelioma) and papillary cystadenolymphoma (Warthin's tumor) are the most common.
• We include several types of tumors here:

Pleomorphic adenoma

• The so-called myxochondroepithelioma.
• The most common tumor of the salivary glands.
• Epithelial tumor, most often in the glandula parotis (and also the most common gl. parotis tumor).
• Mainly in older and middle age, it is slowly growing.

Pleomorphic adenoma, S-100 positive

• Possible relapses.
• The tumor often grows into the capsule, which increases the possibility of malignancy.
• It manifests clinically as a painless swelling.
• Several components alternate in the histological picture - an epitheliomatous component with a trabecular, ductal, acinous or solid arrangement, as well as a myxoid and chondroid component.

Papillary cystadenolymphoma (Warthin's tumor)

• The second most common benign salivary gland tumor.
• Occurrence mainly in gl. parotid and submandibular glands (9% of tumors in gl. parotid).
• After the age of 40, more often men.
• It is usually circumscribed, rigid, well mobile against the substrate, spherical, on sonography it can imitate a cyst.
• Grows slowly.
• 10% recurrence, malignant reversal is very rare.
• It arises from the proliferation of epithelial inclusions in the intraparotic lymph nodes.
• The characteristic histological picture is dominated by a double-layered epithelium with nuclei facing the lumen, the stroma is made up of lymphatic tissue.

Basal cell adenoma

• 70% in gl. parotid, 20% minor glands of the lip.
• Peak incidence in the 7th decade.
• Possible transition to basal cell carcinoma.

Myoepithelioma

• Rare.
• Mainly affects gl. parotid gland.
• May malign.
• Unlike pleomorphic adenoma, they do not form ductal structures.

Oncocytoma

• Occurrence in the 6th to 7th decade, more often in women.
• Grows slowly, is mobile, small (up to 2 cm).
• Forms a case, grey-red in section.
• Recurrences do not occur, malignization only very rarely.
• In the histological image, eosinophilic finely granular cells with an increased number of mitochondria are visible.

Canalicular adenoma

• Incidence over 50 years.
• Usually in the upper lip.

Sebaceous adenoma

• Rare.
• Well circumscribed, cystic, varying in size.

Papilloma ductulation

• Not very common.
• It arises from the epithelium of the ducts of small salivary glands.

Links

Related Articles

• Salivary glands
• Malignant salivary gland tumors

References

• LIŠKA, Karel. Orofacial Pathology. 1. edition. 1983. 

• PAZDERA, Henry. fundamentals of oral and maxillofacial surgery. 1. edition. Olomouc : Palacký University in Olomouc, 2007. 0 pp. ISBN 978-80-244-1670-0.

• WOTKE, George – ŽAMPACHOVÁ, Welcome. Histopathology practicum. 1. edition. 2002. ISBN 80-86297-09-8.

• BRYCHTOVÁ, Svetlana – HLOBILKOVÁ, Alice. Histopathological atlas. 1. edition. 2008. ISBN 978-80-247-1650-3.