Bowen's disease

Bowen's disease (Morbus Bowen, Bowen's dermatosis) is an in situ intraepithelial carcinoma that often progresses to squamous cell carcinoma.

Etiology and clinical manifestation[edit | edit source]

It most often occurs on the trunk and lower limbs in middle-aged and older people. The etiology is multifactorial (UV radiation, chemicals, HPV infections).

Clinically, it appears to be a slowly progressing, sharply demarcated, slightly elevated deposit, round in shape, brown to brownish-red in color, growing to a size of 10 cm. The surface is usually covered with scabs or scales. It is usually accompanied by itching and does not show a tendency to heal. After removing the surface, a wetting base is visible.

The analogy in the genital area is Queyrat's erythroplasia.

Diagnosis and therapy[edit | edit source]

We diagnose it histopathologically - epidermis with acanthosis and a tendency to dyskeratosis, detection of atypical cells and mitoses.

Therapy consists of radical removal of the lesion (surgical, cryotherapy, laser ablation).

Links[edit | edit source]

Virtual preparations[edit | edit source]

https://www.pathowiki.org/pathowiki/index.php/Morbus_Bowen

External links[edit | edit source]

HECHVÁTALOVÁ, H. Kožní prekancerózy. Interní medicína pro praxi [online]. 2004, roč. 6, vol. 11, s. 551-553, dostupné také z <http://www.internimedicina.cz/pdfs/int/2004/11/08.pdf>. ISSN 1803-5256.

Sources[edit | edit source]

HANUŠ, Tomáš. Urologie. 1. vydání. V Praze : Triton, 2011. 207 s. s. 147. ISBN 978-80-7387-387-5.

VOKURKA, Martina a Jan HUGO, et al. Velký lékařský slovník. 6. vydání. 2006. 0 s. ISBN 80-7345-105-0.

ŠTORK, Jiří, et al. Dermatovenerologie. 2. vydání. Praha : Galén, 2013. 502 s. ISBN 978-80-7262-898-8.