Coagulation factors
From WikiLectures
Coagulation cascade:
Coagulation factors are proteins that circulate in plasma in an inactive state. Their main function is to enable hemocoagulation (blood clotting). Most of them are produced by the liver.
| Factor | Name
Alternate Name |
Function |
|---|---|---|
| I | fibrinogen | cleavage of several peptides produces monomeric fibrin, which further forms a fibrin network |
| II* | protrombin | its active form (IIa) activates factors I, V, VII, VIII, XI, XIII, protein C and platelets |
| III | tissue thromboplastin
"tissue factor" |
factor VIIa cofactor |
| IV | Ca2+ | binding of coagulation factors to phospholipids |
| V | proaccelerin, labile factor, accelerating globulin | factor X cofactor – ensure the conversion of prothrombin to active thrombin |
| VI | older name for factor Va | – |
| VII* | proconvertin | activates factors IX, X |
| VIII | antihemophilic factor (AHF)
antihemophilic factor A – antihemophilic globulin (AHG) |
factor IX cofactor |
| IX* | The Christmas Factor
plasma thromboplastic component (PTC) - antihemophilic factor B |
activates factor X |
| X* | Stuart-Prower factor** | activates factor II |
| XI | plasma thromboplastin precursor
plasma thromboplastin antecedent (PTA) - antihemophilic factor C |
activates factor IX |
| XII | The Hageman factor
glass factor |
activates factor XI, VII and prekallikrein |
| XIII | fibrin stabilizing factor
The Laki-Lorand Factor |
|
| von Willebrand factor | binds to factor VIII, enables platelet adhesion | |
| high molecular weight kininogen (HMWK)
The Fitzgerald Factor |
supports the mutual activation of XII, XI and prekallikrein | |
| prekallikrein (PKK)
The Fletcher Factor |
activates factor XII and prekallikrein, cleaves HMWK | |
| kallikrein | ||
| platelet phospholipids |
* vitamin K dependent
** named after the first two patients (Mr R. Stuart and Miss A. Prower) in whom factor X deficiency was described
Links[edit | edit source]
Related articles[edit | edit source]
References[edit | edit source]
- GANONG, William F. Přehled lékařské fyziologie. 20. edition. Galén, 2005. pp. 546–549. ISBN 80-7262-311-7.
- KITTNAR, Otomar, et al. Lékařská fyziologie. 1. edition. Praha : Grada, 2003. 790 pp. ISBN 978-80-247-3068-4.
