Coombs test

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Scheme of direct and indirect Coombs test

The Coombs test (antiglobulin test, AGT) is used to test for the presence of antibodies to erythrocytes. We distinguish 2 variants of the Coombs test:

1. The Coombs direct test is used to diagnose hemolytic anemias caused by anti-erythrocyte antibodies. Using anti-erythrocyte antibodies, we test the presence of these anti-erythrocyte antibodies on the erythrocyte membrane.
2. The Coombs indirect test is used to detect anti-erythrocyte antibodies in the blood plasma of patients after repeated blood transfusions. We use anti-erythrocyte antibodies to test for the presence of anti-erythrocyte antibodies in the blood plasma.

Coombs Test:

Coombs Test 2:

Sources

• KLENER, Pavel. Hematologie. 1. edition. Praha : Galén : Karolinum, 2003. ISBN 8072622102.

• NEČAS, Emanuel – ŠULC, Karel – VOKURKA, Martin. Patologická fyziologie orgánových systémů. Část I. 1. edition. Praha : Karolinum, 2006. ISBN 978-80-246-0615-6.