Cyclopirox

Cyclopirox
cyclopirox
D01AE14
Structural formula of Cyclopirox
Indication	Skin mycoses, gynecological mycoses
Systematic name	6-cyclohexyl-1-hydroxy-4-methylpyridin-2-one

Batrafen® cream, a mass-produced medicinal product with ciclopirox

Ciclopirox is a broad-spectrum antifungal with good penetration into tissues (especially the nail plate), which also acts on spores.  Used for the topical treatment of cutaneous mycoses and fungal vulvovaginitis.

Principle of effect

Ciclopirox enters and accumulates in fungal cells. It binds irreversibly to their cell wall and membrane, ribosomes, mitochondria and microsomes. The mechanism of action is thought to lie primarily in impaired cell membrane function . The uptake of some nutrients by the fungal cell is reduced and at the same time the excretion of some already formed cellular components is increased.

Antimicrobial spectrum

The antimicrobial spectrum of ciclopirox includes dermatophytes, yeasts , fungi and mycoplasmas. However, it also has an antibacterial effect on some gram-positive and gram-negative bacteria. It is also effective for trichomonads.

Links

Reference

1. SKOŘEPOVÁ, Magdalena. Antifungals from the perspective of a dermatologist. Remedia [online] . 2002, vol. 12, no. 1, pp. 51-54, also available from < http://www.remedia.cz/Clanky/Prehledy-nazory-diskuse/Antimykotika-z-pohledu-dermatologa/6-F-fg.magarticle.aspx >. ISSN 0862-8947. 
2. Summary of Product Characteristics: Batrafen cream  [database]. © 2015. Last revision 2015-04-17, [cit. 2018-06-18]. < http://www.sukl.cz/modules/medication/search.php?data%5Bmaterial%5D=Ciklopirox#data-listing >.
3. HAMPL, František and Jaroslav PALEČEK. Pharmacochemistry. 1st edition. Prague: University of Chemical Technology in Prague, 2002. p. 315.  ISBN 80-7080-495-5 .