Drug-induced pulmonary fibrosis
From WikiLectures
Drug-induced pulmonary fibrosis is a development of an intersticial pneumonia and fibrosis due to hypersensitivity or toxic effets of drugs (Template:HVLP, MTX, amiodarone, nitrofurantoin[1], inhalation of O2 in high concentrations):
- hypersensitivity: ATB (penicilin, ampicilin, nitrofurantoin), some cytostatics (MTX),
- direct toxicity: cytostatics (bleomycin, cyclofosfamidTemplate:HVLP) → cytostatic lungs.
It can manifest as an acute or chronic condition.[2]
Symptoms[edit | edit source]
- Dyspnea,
- Dry, irritating cough,
- X-ray: localised / diffuse interstitial damage, late honeycomb lung.
Therapy[edit | edit source]
- Discontinuation of the drug, glucocorticoids.[2]
Resources[edit | edit source]
Related articles[edit | edit source]
References[edit | edit source]
- ↑ GOEMAERE, Natascha NT, Karin GRIJM and Peter Th W VAN HAL, et al. Nitrofurantoin-induced pulmonary fibrosis: a case report. J Med Case Rep [online] . 2008, vol. 2, p. 169, also available from < https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2408600/?tool=pubmed >. ISSN 1752-1947.
- ↑ a b CHILD, P., et al. Internal Medicine. 2nd edition. Prague: Galén, 2007. ISBN 978-80-7262-496-6 .
