Edwards formula
From WikiLectures
The Edwards formula is used to estimate the risk of multifactorial disease.
- r = risk of disability
- p = relative frequency of the disease in the population
The Edwards formula can only be used if the given disease has already occurred in the family (if the disease has not occurred in the family, the risk of occurrence is equal to the relative frequency of the disease in the population) and the calculated risk only applies to first-degree relatives - i.e. parents and children, or siblings. In the event that several 1st degree relatives are affected, we multiply the result by their number. Consanguineous marriages generally increase the risk of disability.
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References[edit | edit source]
- OTOVÁ, Berta. Lékařská biologie a genetika. 1. edition. Praha : Karolinum, 2008. ISBN 978-80-246-1594-3.
- PANCZAK, Aleš, et al. Polygenní dědičnost [online]. ©2008. [cit. 2014-01-11]. <http://biol.lf1.cuni.cz/04Polyg1.pdf>.
