Fibrinolysis
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Fibrinolysis is a minor, but no less important, event in hemostasis. It is necessary to remove the fibrin (hemostatic) plug. In fibrinolysis, fibrin is split by plasmin. The whole system has four components: plasminogen , plasmin , plasminogen activators, plasminogen inhibitors. Plasmin is produced from plasminogen by proteolytic cleavage.
Activators and inhibitors[edit | edit source]
Plasminogen activators are:
- tissue activator (t-PA);
- activator isolated from urine (urokinase type; u-PA).
Plasminogen inhibitors are:
- from α-granules of blood platelets – protects the primary hemostatic plug;
- inhibitors of already formed plasmin;
- α 2 -antiplasmin;
- α 2 -macroglobulin.
They are produced by the cells of the vascular endothelium and the placenta.
Fibrinolysis products[edit | edit source]
Plasminogen is activated to plasmin, which then cleaves fibrin into fragments of different sizes, the so-called fibrin degradation products (FDP). The final cleavage product is D-dimers.
Links[edit | edit source]
Related articles[edit | edit source]
External links[edit | edit source]
References[edit | edit source]
- TROJAN, Stanislav, et al. Medical Physiology. 4., revision and edit the release. Prague: Grada Publishing, as, 2003. 772 pp. ISBN 80-247-0512-5 .[1]
- ↑ TROJAN, Stanislav, et al. Medical Physiology. 4., revision and edit the release. Prague: Grada Publishing, as, 2003. 772 pp. ISBN 80-247-0512-5 .
