Griffith's experiment
Griffith described the phenomenon of transformation in two strains of pneumococci.
The first strain[edit | edit source]
- virulent;
- infectious;
- highly pathogenic;
- kills its hosts (mice);
- encapsulated with polysaccharide capsules;
- they form colonies with smooth edges on the agar.
The second strain[edit | edit source]
- mutant;
- harmless;
- they do not have polysaccharide capsules;
- on agar soil they form colonies with wrinkled, rough edges.
The result of the experiment[edit | edit source]
Griffith killed and disrupted virulent pneumococci and mixed them with live non-virulent pneumococci. After further cultivation, he put these bacteria into the body of mice. The mice became ill later than if they received the same dose of lethal pneumococcus, but the end effect was lethal.
Continuity[edit | edit source]
Griffith's experiment was directly followed by a group around Oswald T. Avery in 1944.
Links[edit | edit source]
Related articles[edit | edit source]
References[edit | edit source]
References[edit | edit source]
AVERY, O T, C M MACLEOD a M MCCARTY. STUDIES ON THE CHEMICAL NATURE OF THE SUBSTANCE INDUCING TRANSFORMATION OF PNEUMOCOCCAL TYPES : INDUCTION OF TRANSFORMATION BY A DESOXYRIBONUCLEIC ACID FRACTION ISOLATED FROM PNEUMOCOCCUS TYPE III. J Exp Med [online]. 1944, vol. 79, no. 2, s. 137-58, dostupné také z <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2135445/?tool=pubmed>. ISSN 0022-1007
Sources[edit | edit source]
- OTOVÁ, Berta. Lékařská biologie a genetika. 1. vydání. Praha : Karolinum, 2008. 123 s. ISBN 978-80-246-1594-3.
