Hepcidin
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| Hepcidin | |
|---|---|
| Gland | liver - hepatocyte |
| Structure | peptide |
| Target organ / tissue | macrophages, enterocytes |
| Receptor | ferroportin |
| Effects | degrades the ferroportin canal - blocks the influx of iron into plasma |
Hepcidin is a hormone synthesized in hepatocytes. It is a peptide that controls Iron metabolism in the body. In the blood is transported to target tissues.In enterocytes and macrophages it blocks the export of iron from the cells . In other words, it keeps the iron in the cell. It was discovered in 2000 in human urine.
Function[edit | edit source]
Iron is absorbed in the duodenum via enterocytes and is transported to the plasma via ferroportin. In the event of hepcidin action ferroportin is degraded and thus the export of iron from the cell is blocked.
Disorders[edit | edit source]
- Hepcidin may be completely absent - juvenile hemochromatosis.
- If there is mutation of hepcidin gene - Hereditary hemochromatosis
Regulation[edit | edit source]
- It is regulated by iron reservoir
- Hepcidin decreases during anemia.
- Hepcidin synthesis decreases with increased activity of erytropoesis.
- Hepcidin synthesis increases during inflammations.
Links[edit | edit source]
Related Articles[edit | edit source]
References[edit | edit source]
- TROJAN, Stanislav – TROJAN, Stanislav. Lékařská fyziologie. 4. edition. Praha : Grada, 2003. 772 pp. ISBN 80-247-0512-5.
- ROKYTA, Richard. Fyziologie a patologická fyziologie : pro klinickou praxi. 1. edition. 2015. 712 pp. ISBN 978-80-247-4867-2.
