Histopathological skin changes
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The skin undergoes the same pathological processes as in other tissues: ie regressive, progressive processes, inflammation, congenital malformations, tumours, circulatory diseases, hyperemia, anemia, hypertrophy and others. In addition, we find special pathological and anatomical changes here.
Pathological-anatomical Changes[edit | edit source]
- Parakeratosis – imperfect corning, in the corner layer preserved flattened nuclei of hornlike cells /in inflammation, in osoriasis).
- Dyskeratosis – a disorder of the cornea, premature keratinization of cells, their plasma produces characteristic horn grains and corpses ("grains" and "corps ronds"; an example of Darier's dyskeratosis, squamous cell carcinoma).
- Acanthosis – enlargement of the malphigan part of the epidermis, multiplication, usually accompanied by elongation and enlargement of interpapillary pin cells (reactions to inflammatory processes, in tumours, etc.).
- Spongiosis - intercellular oedema - enlargement of the intercellular spaces (eczema, dermatitis).
- Intracellular oedema - degenerative cell changes: cavitary, hydroptic, reticular, balloon or vacuolar degeneration (various inflammations).
- Atrophy of the epidermis – loss of various layers (especially stratum spinosum).
- Papillomatosis – a finger-like extension of the papillae of the corium, often together with acanthosis, the papillae may branch at the top (warts, papillomas).
- Acantholysis – the dissolution of desmosomes, between the cells of the cleft to the blister (mostly in the pemphigus). Hyperkeratosis - enlargement of the stratum corneum, other layers narrowed, normal and enlarged (developmental abnormalities, inflammation, tumours, etc.).
- Hyperkeratosis – enlargement of the stratum corneum, ether layers narrowed, normal and enlarged (dwvelopmental abnormalities, inflammation, tumours, etc.).
Dyskeratoic squamous-cell carcinoma.
High magnification micrograph of lichen simplex chronicus, abbreviated LSC. H&E stain. Skin biopsy.
Very high magnification micrograph of pemphigus vulgaris. H&E stain.
References[edit | edit source]
Related Articles[edit | edit source]
Source[edit | edit source]
- BENEŠ, Jiří. Studijní materiály [online]. ©2007. [cit. 2010]. <http://jirben2.chytrak.cz/materialy/dermatovenerologie.doc>.
