Pemphigoid

Bullous pemphigoid

Microscopic image of bullous pemphigoid

Pemphigoid has similar clinical manifestations as pemphigus, but blisters are not determined by the acantholysis and are subepidermal.

The prognosis is more favorable, treatment – corticosteroids and immunosuppressive drugs.

Bullous pemphigoid[edit | edit source]

Parapemphigus or senile pemphigus is an autoimmune disease.

Most often occurs in older people (70–80 years old).

A reliable differentiation from the pemphigus is possible only with histological methods.

Blisters on slightly inflamed base, on limbs, later on the torso, symmetrical; leave pigmentation.

Nikolsky's sign is negative.

The course of the disease is prolonged, a spontaneous remission may also occur.

Sometimes it occurs as paraneoplasia or after drug treatment (penicillin, furosemide, Brufen…).

For scarring, pemphigus is typical of the production of the IgG and IgA against BM with C3 deposits.

It affects the conjunctiva, nasal cavity, pharynx, larynx, nose, genitals, and anus.

Heals with a scar, if it affects the eyes it can cause blindness, leaving the stenosis.

Occurs rather in older individuals.