Prothromplex
Prothromplex is a drug used to treat acute severe bleeding conditions caused by acquired coagulopathy. These are mainly conditions during direct (e.g. NOAC) and indirect ( Warfarin ) anticoagulant therapy. It is a mixture of human coagulation factors II, VII, IX, X, and Protein C. It is produced in a package containing 600 IU in 20 ml. For an idea, it contains as much coagulation factors as 600 ml of frozen plasma.
Indications[edit | edit source]
With regard to possible thrombogenic complications of drug use, the indication must be carefully considered. It is about:
- life-threatening bleeding conditions - given by the volume of blood loss or localization (hemorrhage into the CNS )
- conditions requiring urgent surgery - typically NPB, including damage control surgery
Serious Side effects[edit | edit source]
Development of thromboembolic disease , disseminated intravascular coagulopathy allergic reaction, heart failure or myocardial infarction
Dosage[edit | edit source]
Dosage recommendations are given in units of IU/kg of patient weight.
- in hypocoagulable states in patients on WarfarinTemplate:HVLP
| Hodnota INR | Dávka léčiva |
|---|---|
| 2,0-3,9 | 25 IU/kg |
| 4,0-6,0 | 35 IU/kg |
| nad 6,0 | 50 IU/kg |
- in hypocoagulable states in patients on NOAC therapy - recommended dose 30-50 IU/kg
NOACs cannot be guided by INR
Links[edit | edit source]
Related articles[edit | edit source]
Reference[edit | edit source]
- Summary of Product Characteristics, PROTHROMPLEX TOTAL NF: PROTHROMPLEX TOTAL NF [online]. SÚKL, 2015 [cit. 2016-4-15]. Available from: https://www.sukl.cz/modules/medication/detail.php?code=0075634
- ↑Jump up to:a b c FENGER-ERIKSEN, C. New oral anticoagulants: clinical indications, monitoring and treatment of acute bleeding complications. Acta Anaesthesiologica Scandinavica [online]. 58 n. l., 2014 (6), 651-659 [cit. 2016-04-15]. DOI: 10.1111/aas.12319.
- ↑Jump up to:a b c PEACOCK, W. Frank. Emergency Management of Bleeding Associated With Old and New Oral Anticoagulants. Clinical Cardiology [online]. 2012, 35 (12), 730-737 [cit. 2016-04-15]. DOI: 10.1002/clc.22037.
- ↑Jump up to:a b Life-threatening bleeding - recommended practice consensus opinion [online]. Prague: Czech Hematology Society ČLS JEP [cit. 2016-4-15]. Available from: http://www.hematology.cz/doporuceni/klinika-files/Doporuceni_CHS_CLS_JEP-Zivot_ohrozujici_krvaceni.pdf .
