Psychostimulants
From WikiLectures
Abuse of psychostimulants[edit | edit source]
See cocaine, amphetamines, amphetamine substituted substances and synthetic cathinones
ADHD and other disorders, where we use psychostimulants[edit | edit source]
ADHD[edit | edit source]
- Drugs used : Methylphenidate, dextroamphetamine, methamphetamine, lisdexamfetamin
- Other nonstimulant alternatives with less proven efficacy include clonidine, guanfacine, bupropion, and/or nortriptyline.
- Indication
- ADHD: first-line therapy for patients ≥ 6 years of age
- Mechanism of action: indirect and central sympathomimetic activity → increased release and blocked reuptake of norepinephrine and dopamine (minor effect on serotonin) → increased concentration in the synaptic cleft
Other disorders and their indications[edit | edit source]
- Caffeine (group of methylxanthines): In coffee. Proposed to block adenosine receptors, making oneself less tired
- Depression with suicidality and only a few weeks left to live (e.g. palliative patients)
- Binge-eating disorder (obesity)
- Narcolepsy (Modafinil- nonamphetamine CNS stimulant)
- Hypersomnolence disorder: modafinil or methylphenidate or atomoxetine
Side-effects of stimulants (in general)[edit | edit source]
- Insomnia, anorexia, tachycardia, hypertension, dry mouth, irritability, anxiety...psychoses