Regulation of gene expression by nucleosome acetylation
From WikiLectures
This is an epigenetic regulatory mechanism. Histones are protein complexes containing positively charged amino acids, they bind to negatively charged structures DNA and together form a complex - a nucleosome.
- Histone acetylases: decondense chromatin, facilitate transcription.
- Histone deacetylases: cause chromatin condensation, prevent transcription.
The degree of acetylation is partly controlled by DNA methylation, as histone deacetylases are associated with methylated stretches of DNA.
Links[edit | edit source]
References[edit | edit source]
- NOVOTNÁ, Božena a Jaroslav MAREŠ. biology for medics. 1. edition Praha : Karolinum, 2005. 99 s. ISBN 80-246-1023-X.
