Resistin
| adipose tissue, immunocompetent cells | |
| polypeptid composed of 180 amino acids | |
| lowing the amount of food intake | |
| 605565 |
Resistin is a hormone of adipose tissue, so it belongs to the so-called adipokines. It was discovered in 2001 in connection with insulin resistance research[1].
Structure and synthesis[edit | edit source]
The hormone is produced not only in adipocytes, but also, for example, in the skeletal muscle or in immunocompetent cells. It is a polypeptide with a length of 108 amino acids[1].
Function[edit | edit source]
Resistin is involved in hypothalamic circuits of regulation of food intake. Its effects include:
- reduces food intake,
- regulates sensitivity to insulin,
- acts as a pro-inflammatory cytokine - increases the release of TNF-α, IL-12, increases the expression of cytoadhesive molecules.
It is likely to contribute to insulin resistance at elevated concentrations. Its increased level positively correlates with the amount of adipose tissue. The importance of resistin has been linked to the risk of atherosclerosis, according to some research, it increases the level of LDL cholesterol in the blood.
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Related articles[edit | edit source]
External links[edit | edit source]
References[edit | edit source]
Literature used[edit | edit source]
- KITTNAR, Otomar, et al. Lékařská fyziologie. 1. edition. Praha : Grada, 2011. 790 pp. ISBN 978-80-247-3068-4.
- LEDVINA, M, et al. Biochemie pro studující medicíny II. 2. edition. Praha : Nakladatelství Karolinum, 0000. 0 pp. ISBN 978-80-246-1415-1.
