Talk:Proline
Proline Belongs together with its post-translationally formed derivative hydroxyproline among imino acids. The human body can synthesize it. To a large extent, it participates (again together with hydroxyproline) in the construction and stabilization of the spatial arrangement of collagen. Proline can serve as a source of glucogenic intermediates.
Metabolism of proline[edit source]
Proline can serve as a source of glucogenic intermediates. The precursor of proline is mainly Template:L-glutamate. Oxidation of glutamate produces its γ-semialdehyde, which subsequently cyclizes to pyrroline-5-carboxylate. Hydrogenation then produces proline. As an imino acid proline, as opposed to an amino acid, not subject to transamination.
Degradation in the organism begins with ring cleavage and proceeds as reverse synthesis. Proline therefore produces glutamate and subsequently 2-oxoglutarate, which can participate in energy metabolism. A congenital metabolic block in the degradation pathway results in ``hyperprolinemia. The degradation process is slowed down by the consumption of ethanol. Amino acid accumulates in cells and its increased amount leads to the stimulation of collagen synthesis, which is involved in the development of liver fibrosis.
