Acquired coagulopathy: Difference between revisions

Revision as of 11:31, 19 January 2023

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Acquired defects of factors II, V, VII, IX and X arise in advanced liver diseases, [vitamin K]] deficiency/inhibition.

Absorption disorder of vit. K: obstructive jaundice, malabsorption syndrome (pancreatic / intestinal origin),
coumarin preparations act as inhibitors of vit. K (warfarin, see figure),
in liver diseases, the production of f. II, VII, IX, X, V decreases gradually; u go ahead conditions complex disorder of hemostasis + in addition thrombocytopenia (with splenomegaly), increased fibrinolytic activity (portocaval anastomoses + ↓ detoxification capabilities of the liver),
in liver diseases, hemorrhagic conditions of varying severity, threat to hl. bleeding into the GIT.

Lack of vit. K / overdose of coumarin → administration of vit. K (Kanavit),
at hep. replacement disease: K-plasma, prothrombin complex concentrates, fresh frozen plasma,
antifibrinolytics + glucocorticoids.

KLENER, Pavel, et al. Vnitřní lékařství. 3. edition. 2006. ISBN 80-7262-430-X.

Lack of vit. K / overdose of coumarin → administration of vit. K (Kanavit),
at hep. replacement disease: K-plasma, prothrombin complex concentrates, fresh frozen plasma,
antifibrinolytics + glucocorticoids.

Circulating anticoagulants are agents with an anticoagulant effect; they appear in the blood under pathological circumstances.

KLENER, P. – ET AL.,. Vnitřní lékařství. 3. edition. 2006. ISBN 80-7262-430-X.

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 == Circulating anticoagulants ==
-{{Edituj článek|Circulating anticoagulants}}
-{{:Circulating anticoagulants}}
 '''Circulating anticoagulants''' are agents with an [[anticoagulant]] effect; they appear in the blood under pathological circumstances.
 * (Allo-/auto)[[antibodies]] against coagulation factor (hl. against f. VIII);