Antifibrinolytics

From WikiLectures

  • block the binding of plasmin to fibrin
File:Antifibrinolytics.jpg
The action of antifibrinolytics

Indication[edit | edit source]

  1. during dental procedures in hemophiliacs
  2. during bleeding after surgical interventions (after tonsillectomy) - when replacing coagulation factors

Contraindications[edit | edit source]

  • in the presence of intravascular coagulation

Side effects[edit | edit source]

  • vomiting

Principal Representatives[edit | edit source]

  • Aminocaproic acid
per os or intravenously (administer slowly - this will prevent the possible development of shock and intravascular thrombosis)
reduces the activation of plasminogen
  • Tranexamic acid
the same administration as for aminocaproic acid, but it has a significantly longer effect
  • Aprotinin
used for bleeding in fibrinolysis disorders, or in the treatment of pancreatitis
  • p-aminomethylbenzoic acid (PAMBA)

Links[edit | edit source]

Related Articles[edit | edit source]

Source[edit | edit source]

  • LINCOVÁ, Dagmar – FARGHALI, Hassan. Základní a aplikovaná farmakologie. 2. edition. Galen, 2007. 672 pp. ISBN 978-80-7262-373-0.