Acquired coagulopathy: Difference between revisions
From WikiLectures
Zemanovalex (talk | contribs) (Original text was from WikiSkripta Získané koagulopatie - WikiSkripta [https://www.wikiskripta.eu/index.php?curid=12680]) |
Zemanovalex (talk | contribs) (delete) |
||
| (4 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
[[ | [[File:Farmakodynamika warfarinu.png|thumb]] | ||
== Acquired defects of factors II, V, VII, IX and X == | == Acquired defects of factors II, V, VII, IX and X == | ||
{{:Acquired defects of factors II, V, VII, IX and X}} | {{:Acquired defects of factors II, V, VII, IX and X}} | ||
'''Acquired defects of factors II, V, VII, IX and X''' arise in advanced [[liver]] diseases, [vitamin K]] deficiency/inhibition. | '''Acquired defects of factors II, V, VII, IX and X''' arise in advanced [[liver]] diseases, [vitamin K]] deficiency/inhibition. | ||
| Line 15: | Line 14: | ||
== Circulating anticoagulants == | == Circulating anticoagulants == | ||
'''Circulating anticoagulants''' are agents with an [[anticoagulant]] effect; they appear in the blood under pathological circumstances. | '''Circulating anticoagulants''' are agents with an [[anticoagulant]] effect; they appear in the blood under pathological circumstances. | ||
* (Allo-/auto)[[antibodies]] against coagulation factor (hl. against f. VIII); | * (Allo-/auto)[[antibodies]] against coagulation factor (hl. against f. VIII); | ||
| Line 37: | Line 34: | ||
|strany = | |strany = | ||
|isbn = 80-7262-430-X | |isbn = 80-7262-430-X | ||
}} | }}{{Cite | ||
| type = book | |||
|surname1=Klener|name1=P.|surname2=et al.|title=Vnitřní lékařství|year=2006|edition=3|isbn=80-7262-430-X}} | |||
=== Related Articles === | === Related Articles === | ||
* [[Poruchy hemostázy]] | * [[Poruchy hemostázy]] {{Cite | ||
* [[Warfarin]] | |||
* [[Antikoagulancia]] | | type = web | ||
{{ | |corporation=WikiSkripta|cited=online|url=https://www.wikiskripta.eu/w/Poruchy_hemost%C3%A1zy|source_name=Poruchy hemostázy - WikiSkripta}} | ||
* [[Warfarin]] {{Cite | |||
| type = web | |||
|corporation=WikiSkripta|url=https://www.wikiskripta.eu/w/Warfarin|source_name=Warfarin - WikiSkripta|cited=online}} | |||
* [[Antikoagulancia]] {{Cite | |||
| type = web | |||
|corporation=WikiSkripta|url=https://www.wikiskripta.eu/w/Antikoagulancia|source_name=Antikoagulancia - WikiSkripta|cited=online}} | |||
</noinclude> | </noinclude> | ||
Latest revision as of 11:31, 19 January 2023
Acquired defects of factors II, V, VII, IX and X[edit | edit source]
Acquired defects of factors II, V, VII, IX and X arise in advanced liver diseases, [vitamin K]] deficiency/inhibition.
- Absorption disorder of vit. K: obstructive jaundice, malabsorption syndrome (pancreatic / intestinal origin),
- coumarin preparations act as inhibitors of vit. K (warfarin, see figure),
- in liver diseases, the production of f. II, VII, IX, X, V decreases gradually; u go ahead conditions complex disorder of hemostasis + in addition thrombocytopenia (with splenomegaly), increased fibrinolytic activity (portocaval anastomoses + ↓ detoxification capabilities of the liver),
- in liver diseases, hemorrhagic conditions of varying severity, threat to hl. bleeding into the GIT.
Therapy[edit | edit source]
- Lack of vit. K / overdose of coumarin → administration of vit. K (Kanavit),
- at hep. replacement disease: K-plasma, prothrombin complex concentrates, fresh frozen plasma,
- antifibrinolytics + glucocorticoids.
Links[edit | edit source]
References[edit | edit source]
- KLENER, Pavel, et al. Vnitřní lékařství. 3. edition. 2006. ISBN 80-7262-430-X.
Related articles[edit | edit source]
- Cirkulující antikoagulancia WikiSkripta. Cirkulující antikoagulancia - WikiSkripta [online]. [cit. online]. <https://www.wikiskripta.eu/w/Cirkuluj%C3%ADc%C3%AD_antikoagulancia>.
- Poruchy hemostázy WikiSkripta. Poruchy hemostázy - WikiSkripta [online]. [cit. online]. <https://www.wikiskripta.eu/w/Poruchy_hemost%C3%A1zy>.
Acquired defects of factors II, V, VII, IX and X arise in advanced liver diseases, [vitamin K]] deficiency/inhibition.
- Absorption disorder of vit. K: obstructive jaundice, malabsorption syndrome (pancreatic / intestinal origin),
- coumarin preparations act as inhibitors of vit. K (warfarin, see figure),
- in liver diseases, the production of f. II, VII, IX, X, V decreases gradually; u go ahead conditions complex disorder of hemostasis + in addition thrombocytopenia (with splenomegaly), increased fibrinolytic activity (portocaval anastomoses + ↓ detoxification capabilities of the liver),
- in liver diseases, hemorrhagic conditions of varying severity, threat to hl. bleeding into the GIT.
Therapy[edit | edit source]
- Lack of vit. K / overdose of coumarin → administration of vit. K (Kanavit),
- at hep. replacement disease: K-plasma, prothrombin complex concentrates, fresh frozen plasma,
- antifibrinolytics + glucocorticoids.
Circulating anticoagulants[edit | edit source]
Circulating anticoagulants are agents with an anticoagulant effect; they appear in the blood under pathological circumstances.
- (Allo-/auto)antibodies against coagulation factor (hl. against f. VIII);
- antiphospholipid antibodies (eg. in SLE, antiphospholipid syndrome);
- fibrin/fibrinogen cleavage products during activated fibrinolysis;
- pathologically produced substances of a heparin nature;
- paraprotein in monoclonal gammopathy;
Source[edit | edit source]
References[edit | edit source]
- KLENER, P. – ET AL.,. Vnitřní lékařství. 3. edition. 2006. ISBN 80-7262-430-X.
Related Articles[edit | edit source]
- Poruchy hemostázy WikiSkripta. Poruchy hemostázy - WikiSkripta [online]. [cit. online]. <https://www.wikiskripta.eu/w/Poruchy_hemost%C3%A1zy>.
- Warfarin WikiSkripta. Warfarin - WikiSkripta [online]. [cit. online]. <https://www.wikiskripta.eu/w/Warfarin>.
- Antikoagulancia WikiSkripta. Antikoagulancia - WikiSkripta [online]. [cit. online]. <https://www.wikiskripta.eu/w/Antikoagulancia>.
