Billirubin Question and answer
From WikiLectures
Questions[edit | edit source]
- Which form of bilirubin causes a toxic effect on the basal ganglia ?
- A - conjugated bilirubin
- B - unconjugated bilirubin bound to albumin by van der Waals forces
- C - bilirubin bound to albumin covalently
- D - bilirubin "free" (not bound to albumin)
- Ligandin is a small protein that allows:
- A - binding of bilirubin to glucuronic acid to form mono- and diglucuronide
- B - transfer of bilirubin within the hepatocyte into the smooth plasma reticulum
- C - transfer of conjugated bilirubin via the "bile pole" to the primary bile capillaries
- D - covalent bonding of bilirubin with albumin
| Answers [ show ] |
Case reports[edit | edit source]
Patient with jaundice[edit | edit source]
A 42-year-old patient with severe jaundice, right upper abdominal quadrant pain, pale, with fever and chills.
Laboratory results:
- ALP = 8.4 μkat / l
- cholesterol = 7.9 mmol / l (5-nucleotidase - increased value)
- AST = 0.64 μkat / l
- total bilirubin = 421 μmol / l
- prothrombin time: prolonged, adjusted after vitamin K injection
Questions:
- What is the most likely cause of jaundice in a patient?
- Why is prothrombin time prolonged?
| Answers [ show ] |
Patient with nausea and jaundice[edit | edit source]
Patient admitted with less recent weight loss, nausea , vomiting , who later developed jaundice and enlarged liver.
Laboratory results:
- total bilirubin = 342 μmol / l
- conjugated bilirubin = 171 μmol / l
- ALP = 2.2 μcat / l
- AST = 12.4 μkat / l
- ALT = 11.2 μkat / l
- albumin = 22 g / l
- γ-globulins = 23.8 g / l (34% of total protein)
Questions:
- What is the cause of the patient's illness, which examinations supplement?
| Answers [ show ] |
Links[edit | edit source]
https://www.wikiskripta.eu/index.php?curid=34699
Related Articles[edit | edit source]
- Jaundice
- Hepatitis
- Differential diagnosis of jaundice
| Other chapters from the book MASOPUST, J., PRŮŠA, R .: Pathobiochemistry of metabolic pathways : [ show ] |
Source[edit | edit source]
- MASOPUST, Jaroslav and Richard PRŮŠA. Pathobiochemistry of metabolic pathways. 1st edition. Prague: Charles University, 1999. 182 pp. 125–126. ISBN 80-238-4589-6 .
