Cutaneous B-lymphomas
Primary cutaneous marginal zone B-lymphoma[edit | edit source]
Marginal zone B-lymphoma is characterized by proliferation of small lymphocytes and plasma cells.
Clinical picture[edit | edit source]
(Sub)cutaneous tumors affecting mainly the limbs with solitary or multiple occurrence.
Histopathological image[edit | edit source]
Infiltrates of small lymphocytes , lymphoplasmacytoid cells and plasma cells are clearly visible .
Therapy[edit | edit source]
Radiotherapy has the best results.
Course and prognosis[edit | edit source]
Chronic course with almost 100% survival after 5 years.
Primary cutaneous B-lymphoma from follicular centers[edit | edit source]
It is composed of a mixture of centrocytes and centroblasts. By cells formed from cells in the germinal center.
Clinical picture[edit | edit source]
They usually appear as smooth papules with annular erythema most often on the head, neck or trunk.
Therapy[edit | edit source]
Radiotherapy is most often used simultaneously with excision of the lesion. In more severe cases polychemotherapy.
Course and prognosis[edit | edit source]
Survival 95% at 5 years, but recurrences are possible.
Primary cutaneous diffuse large cell lymphoma of the lower extremities[edit | edit source]
B-lymphoma with a predominance of large lymphocytes forming on the legs. It affects women more often than men over the age of 70.
Clinical picture[edit | edit source]
Red to bluish bumps and tumors on both or one limb. They can also affect other organs.
Histopathological image[edit | edit source]
Diffuse infiltrates with mainly large B-lymphocytes are clearly visible.
Therapy[edit | edit source]
Solitary lesions are treated with radiotherapy, in other cases polychemotherapy is used.
Course and prognosis[edit | edit source]
Chronic course with recurrences with a survival rate of 55% after 5 years.
Links[edit | edit source]
[edit | edit source]
- Cutaneous lymphomas: Cutaneous T-lymphomas ▪ Cutaneous B-lymphomas
- Benign skin tumors
- Precancers in dermatology
- Malignant skin tumors: Melanoma ▪ Basal cell carcinoma ▪ Squamous cell carcinoma ▪ Verrucous carcinoma
- Malignant mesenchymal tumors: Kaposi's sarcoma ▪ Dermatofibrosarcoma protuberans
- Cutaneous pseudolymphomas
- Histiocytosis
- Mastocytosis
- Paraneoplasia
References[edit | edit source]
- ŠTORK, Jiří, et al. Dermatovenerologie. 1. edition. Praha : Galén, Karolinum, 2008. 502 pp. ISBN 978-80-7262-371-6.
ŠTORK, Jiří, et al. Dermatovenerology. 1st edition. Prague: Galén, Karolinum, 2008. 502 pp. ISBN 978-80-7262-371-6.
