Morphine intoxication
From WikiLectures
Opiates are natural substances from opium (juice from unripe poppies). These are morphine , heroin , codeine , etc. They are substances that stimulate opiate - endorphin receptors in the CNS , have a sedative and analgesic effect.
Overdose[edit | edit source]
In case of overdose, there is a depression of consciousness, depression of the respiratory center (brachypnea, apnea) in the medulla oblongata and death. The effect of opiates peaks in 2-3 hours after ingestion.
Clinical picture[edit | edit source]
- Euphoria, Miosis (like pinheads),
- somnolence,
- Hypotension, Bradycardia,
- itchy skin,
- nausea, vomiting, hypotension,
- decrease in intestinal motility, constipation.
Therapy[edit | edit source]
The antidote is the specific opioid antagonist naloxone (Intrenon®), naltrexone
- We give it for signs of respiratory depression, even 0.1 mg after 2 minutes to a dose of 2 mg;
in more severe conditions UPV is required , in case of pulmonary edema oxygen and PEEP .
