Non-alcoholic steatohepatitis
From WikiLectures
Hepatic steatosis is a condition in which the amount of fat (especially triacylglycerols) in the liver exceeds 5% of its weight.
- Pathogenesis
- increased dietary fat intake;
- increased mitochondrial fatty acid synthesis or decreased oxidation;
- impaired release of triacylglycerols from the hepatocyte;
- excess sugars, which are converted into fatty acids;
- hyperalimentation, diabetes mellitus, Wilson's disease, parenteral nutrition, Reye's syndrome.
- Clinical picture
- asymptomatic course or non-specific symptoms: hepatomegaly, abdominal pain, + symptoms of the underlying disease;
- Diagnostics
- slightly elevated aminotransferases, hypertension, hypertriacylglycerolemia, insulin resistance;
- liver ultrasound: increased echogenicity;
- histological picture (small or large droplet, simple steatosis or steatohepatitis);
- Therapy
- elimination of the cause, treatment of metabolic disease.
